术后认知功能障碍与血浆β-淀粉样蛋白及rSO_2的相关性研究

Research on Correlation Between the Postoperative Cognitive Function Disorder and Plasma Beta-amyloid Protein and rSO_2

目的分析术后认知功能障碍与血浆β-淀粉样蛋白(Aβ)及局部脑氧饱和度(rSO_2)的相关性,寻找最佳术后早期认知功能障碍预测截断值。方法选取2015年1月—2016年5月寿光市人民医院住院部收集的患者72例,其中诊断为术后认知功能障碍的患者26例,纳入COPD组,无术后认知障碍者47例,纳入对照组;分析认知功能障碍与血浆Aβ、rSO_2水平相关性。结果以术后24 hrSO_2、血浆Aβ作为预测指标,术后认知功能障碍最佳截断值分别为64.0%、98 pg/L,下曲线面积分别为0.841、0.884。结论术后认知功能障碍与血浆β-淀粉样蛋白及rSO_2的相关性存在相关性,通过改善rSO_2可能有助于降低认知功能障碍发生风险。

Objective To analyze the correlation between the postoperative cognitive function disorder and plasma betaamyloid protein and rSO2 and search for the best early cognitive function disorder after operation in order to predict the cutoff value. Methods 72 cases of inpatients in our hospital from January 2015 to May 2016 were selected and 26 cases of patients with cognitive function disorder after operation were included into the COPD group, and 47 cases of patients without the postoperative cognitive disorder were included into the control group, and the correlation between the postoperative cognitive function disorder and plasma betaamyloid protein and rSO2 was analyzed. Results The postoperative 24 hrSO2 and plasma A[3 were used as the predictive indicators, and the best cutoff values of postoperative cognitive function disorder were respectively 64.0% and 98 pg/L, and the area under the curve was respectively 0.841 and 0.884. Conclusion There is a correlation between the postoperative cognitive function disorder and plasmaβamyloid and rSO2, and the improvement of rSO2 may contribute to reducing the occurrence risks of cognitive function disorder.