急性冠状动脉综合征患者临床特点分析

Analysis of Clinical Features of Patients with Acute Coronary Syndrome

目的探讨分析急性冠脉综合征患者临床特点。方法选择2009年1月—2012年12月该院心内科住院明确诊断的ACS患者383例,SA患者326例。收集患者一般临床资料、生化指标(TC、TG、HDL、LDL、ApoAl、ApoB、Lpa、FPG、UA、Cr、BUN)等。结果两组在年龄、入院时糖尿病、血脂等异常方面差异无统计学意义,ACS组男性比例明显增多(74.9%vs 66.0%,P<0.05),吸烟者ACS组明显高于SA组(36.3%vs 22.7%,P<0.001)。生化指标ACS组HDL水平及APo A水平较SA组降低,分别为HDL[(1.11±0.28)mmol/L vs(1.17±0.29)mmol/L,P<0.05),Apo A[(1.17±0.17)g/L vs(1.21±0.20)g/L,P<0.01];空腹血糖水平ACS组高于SA组[(6.14±2.55)mmol/L vs(5.58±1.68)mmol/L,P<0.01]。结论冠心病患者吸烟、Apo Al和HDL-C水平降低可能是急性冠脉综合征的主要危险因素。

Objective To discuss the clinical features of patienis with acute coronary syndrome. Methods 383 cases of ACS patients and 326 cases of SA patients in the department of cardiology in our hospital from January 2009 to December 2012 were selected and the clinic, and the biochemical indicators such as TC,TG,HDL,LDL,ApoA1,ApoB,Lpa, FPG,UA,Cr and BUN of patients were collected. Results The differences in the age, diabetes at admission and blood fat between the two groups had no statistical significance, the male ratio in the ACS group was obviously increased, （74.9% vs 66.0%,P〈0.05）, the smokers in the ACS group were obviously higher than those in the SA group, （36.3% vs 22.7%, P〈0.001）, and the HDL level and APoA level in the ACS group decreased compared with those in the SA group[（1.11±0.28）mmol/L vs （1.17±0.29）mmol/L,P〈0.05）],[（1.17±0.17）g/L vs （1.21±0.20）g/L, P〈0.01], the fasting blood sugar level in the ACS group was higher than that in the SA group,[（6.14±2.55）mmol/L vs （5.58±1.68）mmol/L, P〈0.01]. Conclusion The decrease of smoking, ApoA1 and HDLC level of patients with coronary heart disease may the major risk factors of the acute coronary syndrome.