双歧杆菌活菌联合蒙脱石散治疗小儿腹泻疗效分析

Analysis of Curative Effect of Bifidobacterium Viable and Montmorillonite Powder in Treatment of Infantile Diarrhea

目的探讨双歧杆菌活菌联合蒙脱石散治疗小儿腹泻的临床疗效。方法依据家属自愿原则及纳入标准,选取2014年6月—2016年6月来该院就诊并确诊为小儿腹泻的90例患儿为研究对象,分为对照组45例和观察组45例,对照组在常规治疗的基础上加用蒙脱石散剂进行治疗,观察组在对照组的基础上加双歧杆菌活菌。观察并记录两组的临床疗效、临床指标改善情况及免疫功能相关指标。结果对照组的有效率为75.56%,低于观察组的91.11%,比较差异有统计学意义(P<0.05);对照组患儿发热消退时间、呕吐缓解时间、腹痛缓解时间、大便恢复正常时间及粪便常规检查正常时间(2.62±1.35)、(2.43±1.15)、(2.42±1.14)、(4.26±1.15)d及(4.98±1.51)d均高于观察组的(1.52±1.23)、(1.26±1.13)、(1.25±1.12)、(2.92±1.12)d及(2.89±1.58)d,各项指标比较差异有统计学意义(P<0.05);在免疫功能指标监测中,对照组和观察组在治疗后均高于本组治疗前状况,且观察组治疗后患儿免疫功能Ig A、Ig G及、CD4/CD8指标(1.76±0.50)、(15.73±0.68)g/L和(1.74±0.27)g/L高于对照组(1.32±0.51)、(10.95±0.64)g/L和(1.38±0.22),比较差异有统计学意义(P<0.05)。结论双歧杆菌活菌联合蒙脱石散治疗小儿腹泻疗能够有效改善临床症状,快速缓解患儿临床不适,提高临床疗效,且能在治疗后有效提高患儿的免疫功能,值得临床应用。

Objective To discuss the curative effect of bifidobacterium viable and montmorillonite powder in treatment of infantile diarrhea. Methods 90 cases of children with diarrhea in our hospital from June 2014 to June 2016 were selected according to the voluntary principle, and divided into two groups with 45 cases in each, the control group adopted the montmorillonite powder on the basis of the routine treatment, the observation group adopted the bifidobacterium viable on the basis of the control group, and the clinical curative effect, clinical indicator improvement and immunity function related indicators of the two groups were observed and recorded. Results The effective rate in the control group was lower than that in the observation group（75.56%vs 91.11%）, and the difference had statistical significance （P〈0.05）, and the fever regression time, vomiting relief time, celialgia relief time, shit recovery normal time and stool routine examination normal time in the control group were higher than those in the observation group [（2.62±1.35）, （2.43±1.15）,（2.42±1.14）,（4.26±1.15）,（4.98±1.51）d vs （1.52±1.23）,（1.26±1.13）,（1.25±1.12）,（2.92±1.12）,（2.89± 1.58）d], and the differences in various indicators had statistical significance, （/9〈0.05）, in the monitoring of immunity function indicators, the immunity function IgA,IgG and CD4/CD8 indicators in the observation group were higher than those in the control group, and the differences had statistical significance by comparison [（1.76±0.50）, （15.73±0.68）g/L and （1.74±0.27） vs （ 1.32±0.51 ）, （ 10.95±0.64）g/L and （ 1.38±0.22）] （P〈0.05）. Conclusion The bifidobacterium viable and montmorillonite powder in treatment of infantile diarrhea can effectively improve the clinical symptoms, rapidly relieve the clinical discomfort of children, improve the clinical curative effect and effectively improve the immunity function after treatment, which is worth clinical application.