发作期抑郁症患者不同情绪面孔刺激下的N170研究

Different emotion faces stimulation in patients with major depressive disorder by Event-related Potential N170

目的探讨高兴、中性、悲伤3种情绪面孔刺激对于发作期抑郁症患者执行持续注意任务时N170的影响;分析发作期抑郁症患者抑郁、焦虑严重程度与N170波幅和潜伏期的相关性。方法选取28例22~69岁抑郁症患者(患者组)和31名20~61岁正常对照者(对照组)。要求被试在高兴、中性、悲伤3种情绪面孔刺激随机呈现后执行注意与选择任务,分别检测被试执行任务时脑电视觉诱发电位,比较患者组和对照组在高兴、中性、悲伤3种情绪面孔诱发的N170波幅和潜伏期,采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)分别评估患者组抑郁、焦虑严重程度。结果与对照组比较,患者组在高兴、中性、悲伤3种情绪面孔刺激下所诱发的头颅局部(T5、T6、O1、O2)N170潜伏期差异有统计学意义(P<0.05),而N170波幅差异无统计学意义(P>0.05)。患者组中性情绪面孔刺激下T5部位N170波幅与HAMD总分存在正相关(r=0.443,P=0.018)。结论发作期抑郁症患者对于不同情绪面孔的初始认知加工有损害,并且抑郁严重程度在部分脑区与中性情绪面孔刺激所诱发的N170波幅有相关性。

Objective To investigate effects of three kinds of neutral, happy, sad emotional faces stimulus on sustained attention task using N170 in depression patients to analysis the correlation of depression in patients with depression, anxiety severity and the amplitude and latency of N170. Methods Twenty-eight patients with depression aged from 22 to 69 years （case group）, and 31 healthy controls （control group） aged from 20 to 61 years were recruited for the study. Subjects were asked to perform tasks in the selection of attention following randomly presented three kinds of happy, neutral and sad emotional faces stimuli. Brain auditory evoked potential including N170 amplitude and latency were recorded during the tasks. HAMD and HAMA were used to assess the severity of depression and anxiety.Results There was significant difference between case group and control group in N170 latency by three kinds of happy, neutral and sad emotional faces stimulation in the local skull （T5, T6, O1, 02） （P〈0.05）. But the difference was not significant in N170 amplitude （P〉0.05）. The total score of HAMD in case group had a positive correlation with N170 amplitude by neutral facial emotion stimulation in part of T5 （r=0.443, P=0.018）. Conclusion There is significant change in the initial cognitive processing of different emotional faces in the patients with depression. And the severity of depression is related to the N170 amplitude induced by the neutral emotional faces stimulation in some parts of brain.