热休克因子1与热休克蛋白对创面愈合的作用及机制研究进展

Advances in the research of effects of heat-shock factor 1 and heat-shock proteins on wound healing and the mechanism

热、炎症和缺血缺氧等应激因素诱导细胞表达保护性蛋白——热休克蛋白（HSP），热休克因子（HSF）是调节该蛋白的关键因子。在哺乳动物细胞中，应激因素刺激引起HSF1活化可致HSP表达增加，且与诸多存在于应激后细胞保护和修复通路中基因表达的调节密切相关。阻断HSF1表达，虽然不会影响HSP正常状态下的基础表达，但是HSP在热和其他应激因素刺激后表达增加的现象将被完全抑制。

Heat-shock proteins （HSPs） are the protective proteins expressed by cells under stress. Heat-shock factors （HSFs） are the key factors to regulate HSPs. Researches about the effects of HSF1 and HSPs in cells after stress and the mechanism have become the important entry, point to explore the cell response in wound healing after trauma. This article reviews the effects of HSPs and HSFI which regulate the proteins on wound healing and the mechanism, so as to deliver message for studying effects of intervening HSF1 on expression of HSPs and wound healing and the mechanism.