NOD样受体热蛋白结构域3炎性体与心肌缺血再灌注损伤

NOD-like receptor pyrin domain containing 3 inflammasome and myocardial ischemia-reperfusion injury

心肌缺血再灌注损伤(myocardial ischemia-reperfusion injury,MI/RI)是一个多种因素共同参与、相互作用的炎症级联反应过程。NOD样受体热蛋白结构域3(NOD-like receptor pyrin domain containing 3,NLRP3)炎性体作为固有免疫系统的重要组成部分在MI/RI的炎症损伤过程中扮演关键角色。此外,阻断或抑制NLRP3炎性体激活及其下游炎症因子释放可能成为MI/RI新的治疗靶点。

Myocardial ischemia-reperfusion injury （MI/RI） is an inflammatory cascade process involving the interaction of multiple factors. In recent years, more and more evidence suggests that NOD- like receptor pyrin domain containing 3 （NLRP3） inflammasome, an important component of the innate immune system, is closely associated with the inflammatory damage of MI/RI. Furthermore, blockage of NLRP3 inflammasome or the release of its downstream pro-inflammatory cytokines may provide new therapeutic targets for this disorder.