纳米碳混悬注射液在尿毒症继发性甲状旁腺功能亢进甲状旁腺全切术中的应用——2例报告及文献复习

Application of carbon nanoparticles suspension injection in uremic patients with secondary hyperparathyroidism underwent total parathyroidectomy: 2 case report and literature review

药物治疗无效的尿毒症继发性甲状旁腺功能亢进患者,可行甲状旁腺全切术,缓解患者的溶骨破坏。术中彻底切除双侧甲状旁腺是手术成功的关键。中南大学湘雅三医院对2例继发性甲旁亢患者施行甲状旁腺全切术,术中采用纳米碳混悬注射液负显影标记技术,找到全部4个增生的甲状旁腺,术后疗效满意,患者甲状旁腺激素均显著降低,骨痛、瘙痒临床症状缓解消失。在尿毒症继发性甲旁亢行甲状旁腺全切术中,采用纳米碳混悬注射液负显影技术,有利于良好地显露和切除双侧甲状旁腺,有利于保护正常甲状腺和喉返神经,值得推广。

Total parathyroidectomy （PTX） can be used to treat secondary hyperparathyroidism （SHPT） in uremic patients, relieving the patient＇s osteolytic destruction. Complete resection of bilateral parathyroid glands is key to successful operation. Recently, 2 patients successfully received surgical treatment, in which carbon nanoparticles suspension injection were used. With the help of carbon nanoparticles suspension injection, all of the 4 hyperplastic parathyroid glands were found successfully. The parathyroid hormone（PTH） was significantly decreased after operations and the clinical symptoms were relieved simultaneously. We conclude that the use of carbon nanoparticles suspension injection is helpful for total parathyroidectomy operation in uremic patients with SHPT,which can protect the normal thyroid and recurrent laryngeal nerve.