表观遗传与肝纤维化发生

Epigenetics and liver fibrogenesis

表观遗传修饰是指一系列不改变DNA序列但可引起基因表达改变的调节过程。表观遗传机制包括DNA甲基化、组蛋白修饰和调节性非编码RNAs参与调节肝星状细胞活化和肝纤维化发生。深入了解肝纤维化的表观遗传调节机制有助于发现新的诊断标志物以及抗纤维化治疗方法。

Epigenetic modification refers to a variety of regulating processes that may induce the changes in gene expression without altering DNA sequence. Epigenetic mechanisms including DNA methylation, histone modification, and regulatory non-coding RNAs are involved in hepatic stellate cell activation and liver fibrogenesis. A deep understanding of epigenetic mechanisms in liver fibrosis helps to identify new markers and therapies for liver fibrosis.