冠心病中医证型与红细胞分布宽度及血小板平均体积相关性的临床观察

Correlative study between TCM syndromes of coronary heart disease and red blood cell distribution width and mean platelets volume

目的探讨研究冠心病各中医证型与血常规中两常规化验指标红细胞分布宽度(RDW)和血小板平均体积(MPV)之间的相关性。方法将326例经冠脉造影检查后确诊为冠心病的患者按中医辨证分为气滞、寒凝、血瘀、痰浊、气虚、阴虚、阳虚(阳脱)7个证型,检测其血常规中RDW和MPV水平,并进行比较。结果气滞及兼证、非气滞证两组比较,血瘀及兼证、非血瘀证两组比较,痰浊兼证、非痰浊证两组比较,气虚及兼证、非气虚证两组比较,阴虚及兼证、非阴虚证两组比较,阳虚及兼证、非阳虚证两组比较,RDW、MPV差异均有统计学意义(P<0.05),寒凝及兼证、非寒凝证两组比较,RDW、MPV差异无统计学意义(P>0.05);RDW、MPV值由气滞证、寒凝证、血瘀证、痰浊证、气虚证、阴虚证到阳虚证逐渐增大。结论 RDW、MPV与冠心病各中医证型有相关性,可一定程度上揭示冠心病在各中医证型间传变规律,为冠心病中医证型分型及其标准化研究提供客观依据。

Objective To explore the relativity between TCM syndromes of coronary heart disease（ CHD） and the plasma concentration of two routine laboratory test index of blood routine ： red blood cell distribution width（ RDW）,mean platelets volume（ MPV）. Methods 326 CHD patients diagnosed by coronary angiography examination were divided into 7 TCM syndromes,Qi stagnation syndrome（ QSS）,cold coagulation syndrome（ CCS）,blood stasis syndrome（ BSS）,phlegm turbid syndrome（ PTS）,Qi deficiency syndrome（ QDS）,Yang asthenia syndrome（ YAS）,Yin deficiency syndrome（ YDS）,and the plasma concentrations of RDW and MPV were measured and compared. Results Differences of RDW,MPV have statistics significance in comparison between QSS and accompanied syndromes and non-QSS,BSS and accompanied syndromes and non-BSS,PTS and accompanied syndromes and non-PTS,QDS and accompanied syndromes and non-QDS,YAS and accompanied syndromes and non-YAS,YDS and accompanied syndromes and non-YDS,（ P 〈 0. 05）. Differences of RDW,MPV have no statistics significance in comparison between CCS and accompanied syndromes and non-CCS,（ P 〉 0. 05）. And the value of RDW and MPV gradually increase with QSS,CCS,BSS,PTS,QDS,YAS and YDS. Conclusion There are the relativity between RDW and MPV and TCM syndromes of CHD,and they can indicate the CHD,and as a reference to explore the relativity between TCM syndromes of CHD.