天山假狼毒根中一个新倍半萜

A new sesquiterpenoid from the roots of Stelleropsis tianschanica

采用硅胶、Sephadex LH-20、ODS等柱色谱技术,从天山假狼毒根的二氯甲烷提取部位中分离得到了3个愈创木烷型倍半萜类化学成分,根据理化性质和波谱数据鉴定为(+)-guaia-l(10),ll-dien-9-one-5α-hydroxy(1)、4β,5βH-guai-9,7(11)-dien-12,8-olide-1α,8α-diol(2)、4α,5βH-guai-9,7(11)-dien-12,8-olide-1α,8α-diol(3)。其中,化合物1为新化合物,化合物3首次从该属植物中分离得到。

Three sesquiterpenoids were isolated from the dichloromethane extract of the roots of Stelleropsis tianschanica Pobed through a combination of various chromatographic approaches, including silica gel, Sephadex LH-20, reverse phase C_（18） and so on. On the basis of spectroscopic data analysis, they were identified as（＋）-guaia-l（10）,ll-dien-9-one-5α-hydroxy（1）, 4β,5βH-guai-9,7（11）-dien-12,8-olide-1α,8α-diol（2）, 4α,5βH-guai-9,7（11）-dien-12,8-olide-1α,8α-diol（3）. The compound 1 is a new sesquiterpenoid, and the compound 3was isolated for the first time from the genus Stelleropsis.