荷丹片对冠心病合并2型糖尿病患者血脂、炎症因子及氧化应激水平的影响

Effects of Hedan Tablets on the Levels of Blood Lipid,Inflammatory Factors and Oxidative Stress in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus

目的:探究荷丹片对冠心病合并2型糖尿病患者血脂、炎症因子及氧化应激水平的影响及安全性。方法:收集2013年7月-2015年11月我院收治的冠心病合并2型糖尿病患者118例,按随机数字表法分为观察组(63例)和对照组(55例)。对照组患者给予控制血糖、调节血脂、扩张血管、抗凝等常规治疗;观察组患者在对照组基础上餐前口服荷丹片1.46 g,tid。两组患者均连续治疗6个月。比较两组患者治疗前后血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、血清炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素10(IL-10)、IL-6、超敏C反应蛋白(hs-CRP)]、血清氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)]水平及不良反应发生情况。结果:治疗前,两组患者血脂、炎症因子及氧化应激指标水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者TC、TG、LDL-C、TNF-α、IL-6、hs-CRP、MDA水平显著降低,IL-10、SOD、NO水平显著升高,且观察组上述指标均显著优于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:荷丹片能有效改善冠心病合并2型糖尿病患者血脂及血清炎症因子水平,减轻炎性损伤,降低氧自由基水平,增强机体抗氧化能力,减轻氧化应激损伤,且安全性较高。

OBJECTIVE：To explore the effects and safety of Hedan tablets on the levels of blood lipid,inflammatory factors and oxidative stress in coronary heart disease（CHD）patients with type 2 diabetes mellitus（DM2）. METHODS：A total of 118 patients diagnosed as CHD with DM2 were collected from our hospital during Jul. 2013-Nov. 2015,and then divided into observation group（63 cases）and control group（55 cases）according to random number table. Control group received conventional treatment such as controlling blood glucose,regulating blood lipid,vasodilator,anticoagulant. Observation group additionally received Hedan tablets 1.46 g before meal,tid,on the basis of control group. Both groups received treatment for 6 months. The levels of blood lipid（TC,TG,LDL-C,HDL-C）,serum inflammatory factors（TNF-α,IL-10,IL-6,hs-CRP） and oxidative stress indexes（MDA,SOD,NO）before and after treatment as well as the occurrence of ADR were compared in 2 groups. RESULTS：Before treatment,there was no statistical significance in levels of blood lipid,serum inflammatory factors or oxidative stress indexes between 2 groups（P〈0.05）. After treatment,the serum levels of TC,TG,LDL-C,TNF-α,IL-6,hs-CRP and MDA in 2 groups were decreased significantly,while those of IL-10,SOD and NO were increased significantly;the observation group was significantly better than the control group,with statistical significance（P〈0.05）. There was no statistical significance in the incidence of ADR between 2 groups（P〈0.05）. CONCLUSIONS：Hedan tablets can effectively improve the level of blood lipid,reduce the level of inflammatory factors,relieve inflammatory injury,reduce the level of oxygen free radical,strengthen antioxidant capacity and lighten oxidative stress injury with good safety.