血清25(OH)D_3水平与慢性丙型肝炎相关性的Meta分析

The relationship between 25 hydroxyvitamin D level and chronic hepatitis C:a Meta-analysis

目的评价血清25羟维生素D_3[25(OH)D_3]水平与慢性丙型肝炎(CHC)的关系。方法计算机检索Cochrane Library、Medline、Pubmed、中国生物医学文献数据库(CBM)、中文科技期刊数据库(VIP)、中国期刊全文数据库(CNKI)、万方数字化期刊全文数据库收录的文献,检索年限均为建库至2017年3月1日,检索所有评价人体血清25(OH)D_3水平与慢性丙型肝炎关系的中英文文献。采用RevMan 5.2软件和Stata12.0软件进行数据分析。结果最终纳入12篇文献1 144例患者,Mate分析结果显示,CHC组患者体内25(OH)D_3水平较对照组低1.59ng/ml(SMD=-1.59,95%CI-2.37^-0.80,P<0.01)。按种族进行分析,黄种人和埃及人CHC组患者25(OH)D均较对照组低(SMD=-2.48,95%CI-3.58^-1.38,P<0.01;SMD=-2.10,95%CI-3.23^-0.96,P<0.01),而白种人差异无统计学意义(SMD=-0.20,95%CI-1.42^-1.03,P=0.75)。根据维生素D检测方法进行分析,在酶联免疫法(ELISA)亚组和色谱法亚组中,CHC组患者的血清25(OH)D_3均较对照组低(SMD=-2.39,95%CI-3.22~~1.56,P<0.01;SMD=-1.751,95%CI-2.06^-1.44,P<0.01)。结论慢性丙型肝炎患者25(OH)D_3水平较正常人低。

Objective To review the relationships between 25 hydroxyvitamin D3[25（OH）D3]levels and chronic hepatitis C.Methods We searched Cochrane Library,Medline,PubMed,Chinese Biomedical Literature Database（CBM）,VIP,CNKI,and Wanfang database of English and Chinese studies reporting the relationship between 25 hydroxyvitamin D levels and chronic hepatitis D form establish of the database to March 1,2017.Results Twelve studies（n=1 144）were finally included,737 cases in CHC group and 407 in control group.The results of meta-analysis showed that 25（OH）D3 in patients with CHC was lower than the control group individuals（SMD=-1.59,95%CI-2.37～-0.80,P＆lt;0.01）.The subgroup analysis of ethnicity,the CHC group was lower than the control group in the serum 25（OH）D3 levels for both Asian and Egyptian（SMD=-2.48,95%CI-3.58～-1.38,P＆lt;0.01;SMD=-2.10,95%CI-3.23～-0.96,P＆lt;0.01）,while there was no statistical difference for White（SMD=-0.20,95%CI-1.42～-1.03,P=0.75）.In the subgroup analysis of detection method for 25（OH）D3,both of ELISA and chromatography showed that the serum 25（OH）D3 levels in CHC group was lower than the control group（SMD=-2.39,95%CI-3.22～-1.56,P＆lt;0.01;SMD=-1.75,95%CI-2.06～-1.44,P＆lt;0.01）.The result of the study showed no bias and reliable according to publication bias analysis and sensitivity analysis.Conclusion The 25 hydroxyvitamin D level was lower in chronic hepatitis C patients than health control.Due to the small of sample sizes,more high quality,large sample studies are needed to verify the results.