血,尿β2微球蛋白测定在心力衰竭高血压病中的意义

SIGNIFICANCE OF SERUM AND URINE BETA_2-MICROGLOBULIN IN PATIENTS WITH CONGESTIVE HEART FAILURE AND HYPERTENSION

本文测定50例心力衰竭、37例高血压患者及30例正常人的血、尿β_2微球蛋白(β_2-MG)浓度。结果显示,两组患者的血、尿β_2-MG水平均显著高于正常人(P<0.001),随着心衰程度或高血压病程度加重,血、尿β-MG逐渐升高,血清β_2-MG与血肌酐高度正相关。提示血、尿β_2-MG可作为评价心功能损害和高血压性肾功能损害程度的客观敏感指标。

Serum and urine beta_2-microglobulin (β_2-MG) levels were determined by radioimmunoassay in 50 patients with congestive heart failure, 37 patients with hypertension and 30 normal subjects. The results showed that serum and urine levels of β_2-MG in patients with congestive heart failure or hypertension were much higher than those in normal subjects (p<0.001). The more serious the congestive heart failure or hypertension, the higher the β_2-MG levels. In patients of class Ⅰ congestive heart failure or hypertension, the serum β_2-MG level was higher that in normal subjects(p<0.01). Serum β_2-MG concentration was positively correlated with plasma creatinine in two groups of patients. The results of this study suggests that β_2-MG may be a sensitive index of congestive heart failure and renal dysfunction in hypertension.