黄连素冷湿敷治疗皮炎湿疹急性期病变的临床疗效

Clinical study on the effectiveness of Berberine cool wet compress therapy in the acute phase of eczemay

目的观察黄连素溶液湿敷治疗皮炎湿疹急性期病变的效果。方法选取2014-11至2016-11火箭军总医院收治的190例皮炎湿疹急性期病变患者。以掷币法将患者随机分为观察组(n=95)和对照组(n=95)。在常规药物治疗基础上,观察组给予黄连素溶液冷湿敷,用纱布浸透药液,敷于患处,3~5 min更换1次,共30 min,2次/d;对照组给予3%硼酸溶液冷湿敷,方法同观察组。比较两组的临床疗效,治疗前后积分及消退时间。结果治疗1周后,两组等级疗效比较,差异无统计学意义(Z=-1.026,P=0.305),但进一步比较显示,观察组治愈率和总有效率均优于对照组(χ~2=4.380,P<0.05;χ~2=5.640,P<0.05)。其余未治愈者继续原治疗或调整药物后均基本治愈,治疗期间两组均未发现明显不良反应。观察组和对照组治疗前后积分比较,差异均具有统计学意义(t=33.890,P<0.001;t=31.275,P<0.001);观察组炎性渗出消退时间比对照组明显缩短(P<0.05);观察组平均治愈时间明显短于对照组(P<0.05)。结论黄连素冷湿敷可治疗急性期湿疹,效果显著,为治疗急性湿疹提供参考。

Objective This study objective was to observe the effect of Berberine cool wet compress therapy on the acute phase of eczema. Methods A total sample of 190 dermatitis eczema patients with acute lesions treated in the General Hospital of Rocket Army from November 2014 to November 2016 was selected for the study. The patients were randomly divided into an observation group （n=95） and a control group （n=95） by means of random sampling. The observation group was treated with Berberine cold wet compress acheived by soaking gauze into liquid Berberine, compressing it on the injured part, replacing it every 3-5 min for a total of 30 min, twice daily. The control group was treated with cold wet compress of 3% boric acid solution, applied with the same frequency as the observation group. The clinical effect, integral before and after treatment and the regression time of two groups were compared. Results The difference of effect 1 week after treatment between two groups was not statistically significant （Z= - 1.026, P=0.305 ）. However, further comparison showed that the cure rate and total effective rate were better than those of the control group （χ^2=4.380, P〈0.05; χ^2=5.640, P〈0.05）. The rest uncured are basically cured after continuing the original treatment or adjusting drugs, with no obvious adverse reactions occurred during treatment. The difference of integral between observation group and control group before and after treatment was statistically significant （t=33.890, P〈0.001 ; t=31.275, P 〈 0.001）; inflammatory exudation regression time of the observation group was shorter than that of control group （P 〈 0.05）; the average healing time of observation group was shorter than that of control group （P〈0.05）. Conclusions Berberine cold wet compresses can be used to treat acute eczema, which has a positive effect on outcome and provides reference for clinical treatment of acute eczema.