急性脑梗死应用阿托伐他汀的整体疗效及血脂优化效果评析

Analysis of Holistic Curative Effect and Blood Fat Optimization Effect of Atorvastatin in Treatment of Acute Cerebral Infarction

目的研究急性脑梗死应用阿托伐他汀的整体疗效及对血脂的优化效果与用药安全性。方法抽选86例于2013年10月—2015年10月在该院接受治疗的急性脑梗死患者作为此次研究的观察对象,随机分为对照组与研究组,各入组43例。两组患者均接受"基础治疗+阿托伐他汀"的用药方案,对照组的阿托伐他汀用药剂量为20 mg/d,研究组的用药及了为40 mg/d,持续给药2个月后,以疗效、血脂指标变化等为标准对两组用药效果予以评析,并观察用药的安全。结果研究组的临床总好转率为95.3%,比较于对照组的74.4%显著更高(P<0.05);对比两组治疗前,TC、TG、HDL-C及LDL-C等血脂指标差异无统计学意义(P>0.05),在治疗后两组的血脂指标均均得以优化(P<0.05),而研究组的优化效果显著更优(P<0.05)。两组患者入组后均未见明显严重不良反应。结论急性脑梗死应用阿托伐他汀强化降脂治疗可显著改善患者的血脂水平,提升疗效,且用药安全性较高,建议临床重视并加以推广应用。

Objective To research the holistic curative effect and blood fat optimization effect of atorvastatin in treatment of acute cerebral infarction. Methods 86 cases of patients with acute cerebral infarction treated in our hospital from October 2013 to October 2015 were selected as the research objects and randomly divided into two groups with 43 cases in each, both groups were given the basic treatment and atorvastatin, and the control group were treated with 20mg/d atorvastatin, and the research group were treated with 40mg/d atorvastatin, after the 2-month continuous admin- istration, the medication effect was analyzed according to the curative effect and blood fat indicators, and the medication safety was observed. Results The total improvement rate in clinical in the research group was obviously higher than that in the control group（95.3% vs 74.4%）, and before treatment, and the differences in the TC,TG,HDL-C and LDL-C between the two groups had no statistical significance（P〉0.05）, after treatment, the blood fat indicators of the two groups were optimized（P〈0.05）, and the optimization effect in the research group was obviously better（P〈0.05）, and there were＇no severe adverse reactions. Conclusion The application of atorvastatin Intensive lowering of blood lipid treatment for acute cerebral infarction can obviously improve the blood fat level of patients and improve the curative effect with higher medication safety, which is suggested to be promoted and applied in clinic.