胎膜早破治疗中生物蛋白胶封堵的临床应用观察

Observation on Clinical Application of Premature Rupture of Fetal Membranes in Treatment of Biological Fibrin Glue

目的观察胎膜早破治疗中运用生物蛋白胶封堵的临床成效。方法选取重庆市彭水县中医院2015年11月—2016年6月妇产科入院的胎膜早破患者80例,随机分为观察组和对照组各40例。给予对照组期待疗法,给予观察组生物蛋白胶封堵治疗。对治疗总有效率、不良反应发生率及治疗后分娩情况进行对比。结果观察组治疗总有效率为95.0%,对照组75.0%,观察组治疗总有效率明显优于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为15.0%,对照组为37.5%,观察组不良反应发生率明显低于对照组;观察组孕妇自然分娩率、人工助产率、剖宫产率及胎儿存活率分别为75.0%、20.0%、5.0%及100.0%,对照组分别为50.0%、25.0%、25.0%、80.0%,观察组自然分娩率及胎儿存活率明显高于对照组,人工助产率及剖宫产率显著低于对照组,差异有统计学意义(P<0.05)。结论胎膜早破治疗中运用生物蛋白胶封堵的临床成效显著,能有效提高优化分娩结局,降低不良反应发生,应大力推广应用。

Objective To observe the clinical effect of premature rupture of fetal membranes in treatment of biological fibrin glue. Methods 80 cases of patients with premature rupture of fetal membranes admitted and treated in the department of gynaecology and obstetrics in our hospital were selected and randomly divided into two groups with 40 cases in each, the control group were treated with expectant treatment, while the observation group were treated with biological fibrin glue, and the total effective rate, incidence rate of adverse reactions and delivery after treatment were compared. Results The total effective rate in the observation group was obviously better than that in the control group with statistical significance（95.0% vs 75.0%）,（P〈0.05） and the incidence rate of adverse reactions in the observation group was obviously lower than that in the control group,（15.0% vs 37.5%）, and the natural delivery rate, artificial midwifery rate, cesarean rate and survival rate of fetuses were respectively 75.0%,20.0%,5.0% and 100.0% in the observation group and 50.0% ,25.0%,25.0%,80.0% in the control group, and the natural delivery rate and survival rate of fetuses in the observation group were obviously higher than those in the control group, and the artificial midwifery rate and cesarean delivery rate were obviously lower than those in the control group, and the differences between groups had statistical significance（P〈0.05）. Conclusion The clinical effect of premature rupture of fetal membranes in treatment of biological fibrin glue is obvious, which can effectively improve the delivery outcome and reduce the occurrence of adverse reactions, and it should be greatly promoted and applied.