摘要
采用常压敞开式离子化结合离子迁移谱技术,研究建立了蜡笔、水贴纸、橡皮泥等玩具样品中14种致癌致敏染料的快速筛查方法。无需繁琐的样品前处理过程,玩具样品经纸喷雾或萃取纳升喷雾,将上样、萃取、电离等步骤集成为一步实现,并在16 ms内完成了离子迁移谱分析检测。同时还对疑似阳性样品建立了超高效液相色谱-串联质谱的确证方法。14种致癌致敏染料的检出限为0.5~2 mg/kg。该方法流程便捷、快速高效,适用于玩具样品的现场快速筛查。
A rapid analytical method was developed for the screening of 14 carcinogenic and sensiti- zing colorants in toys （e. g. crayon, temporary tattoo sticker and modeling clay） using ionization cou- pled with ion mobility spectrometry. Without any tedious pretreatment, sampling, extraction and i- onization were integrated by paper spray or extraction nano-electrospray. The instrumental analysis time for a single ion mobility spectrometry run was less than 16 ms. The suspicious positive samples were subjected to further verification by ultra-performance liquid chromatography - tandem mass spec- trometry（ UPLC- MS/MS）. The limits of detection （LODs） for the 14 carcinogenic and sensitizing colorants in toys ranged from 0.5 mg/kg to 2 mg/kg. The established method is simple, convenient and suitable for rapid, on-site screening of toy products.
作者
吕悦广
郭项雨
马强
白桦
孟宪双
胡明珠
马龙华
吴青
何裕建
杨镜奎
LU Yue-guang GUO Xiang-yul MA Qiang BAI Hua MENG Xian-shuang HU Ming-zhu MA Long-hua WU Qing HE Yu-jian YANG Jing-kui(Chinese Academy of Inspection and Quarantine, Beijing 100176, China School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 101407, China Excellims Corporation, Acton, MA 01720, USA)
出处
《分析测试学报》
CAS
CSCD
北大核心
2017年第8期949-954,共6页
Journal of Instrumental Analysis
基金
国家重点研发计划(2016YFF0203704
中央级公益性科研院所基本科研业务费专项资金资助项目(2016JK004)
关键词
纸喷雾
萃取纳升喷雾
离子迁移谱
玩具
致癌致敏染料
paper spray
extraction nano-electrospray
ion mobility spectrometry
toys
carcino-genic and sensitizing colorantsT.7- I~ ~~~.^-~4-.--P：.3
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