经尿道电切联合围术期膀胱热灌注治疗老年膀胱癌的疗效

Efficacy of transurethral rescetion of bladder tumor combined with perioperative bladder perfusion in the treatment of elderly bladder cancer

目的总结经尿道电切(TURBT)联合围术期膀胱热灌注治疗老年膀胱癌的临床疗效。方法选择我院2010—2015年收治的60例老年膀胱癌患者,根据治疗方案不同分为试验组和对照组。试验组30例患者接受TURBT联合围术期膀胱热灌注治疗,对照组30例患者接受TURBT联合常规膀胱灌注治疗。对比两组患者临床疗效。结果试验组症状改善率为90.00%,明显高于对照组的50.00%(P<0.05)。试验组肿瘤总复发率为6.67%,对照组为30.00%;试验组药物毒副反应总发生率为6.67%,对照组为10.00%,试验组肿瘤总复发率优于对照组(P<0.05),而两组毒副反应总发生率差异不显著(P>0.05)。结论 TURBT、围术期膀胱热灌注联合治疗老年膀胱癌症状改善显著,对患者近期生活质量的提高有积极意义。

Objective To summarize the clinical efficacy of transurethral rescetion of bladder tumor （TURBT） combined with perioperative bladder perfusion in the treatment of elderly bladder cancer. Methods Sixty cases of elderly patients with bladder cancer who were treated in our hospital from 2010 to 2015 were selected, which were randomly divided into experimental group and control group according to the treatment methods. Thirty cases in the experimental group underwent TURBT combined with perioperative bladder perfusion therapy, while 30 cases in the control group underwent TURBT combined with conventional postoperative perfusion. The clinical efficacy between the two groups were compared. Results The symptom improvement rate was 90.00% in the experimental group which was higher than 50.00% in the control group （P〈0.05）. The total recurrence rate was 6.67% in the experimental group and 30.00% in the control group; the total incidence of drug side effects was 6.67% in the experimental group and 10.00% in the control group. The recurrence rate in the experimental group was better than the control group （P〈0.05）, but the difference in the drug side effect between the two groups was not significantly （P〈0.05）. Conclusion TURBT combined with perioperative bladder perfusion in treatment of elderly bladder cancer can significantly improve clinical symptoms, which has a positive effect on the improvement of patients＇ quality of life.