癌症免疫治疗临床新进展

Progress on Clinical Immunotherapy of Malignant Tumor

肿瘤免疫治疗是一种利用患者自身免疫系统实现抗肿瘤作用的治疗方式,现已成为对抗肿瘤的新型有效疗法.然而,抑制性肿瘤微环境的存在可使肿瘤免疫治疗的效果大打折扣.本文将以肿瘤微环境的组成、分类及其对治疗效果的影响为出发点,探讨通过放化疗、免疫检查点、基因修饰免疫细胞以及多种联合治疗等方式应对抑制性肿瘤微环境,使免疫治疗发挥最大疗效.

Tumor immunotherapy has now become a new effective therapy against cancer, as a way to use the patient＇s own immune system to achieve anti-tumor effect. However, the presence of inhibitory tumor microenvironment can greatly reduce the effect of immunotherapy. Base on the tumor microenvironment composition, classification and the effect of treatment, we explore ways to deal with the inhibition of tumor microenvironment through radiotherapy, chemotherapy, checkpoints, gene modified immune cells and combination therapy, to make the greatest effect of immunotherapy.