中医药治疗肿瘤相关性贫血疗效的Meta分析

A Systematic Review on the Clinical Efficacy of Traditional Chinese Medicine in Treating Cancer Related Anemia

目的:证实中医药治疗肿瘤相关性贫血的疗效,为治疗肿瘤相关性贫血的研究提供更科学客观的依据。方法:研究对象为2010—2014年间公开发表的以中医药治疗恶性肿瘤相关性贫血为观察组,以无中医药参与肿瘤相关性贫血治疗为对照组的完全随机对照研究文献。采取全文检索的方式,中文检索词包括贫血、恶性肿瘤、癌、中医药、中药等。电子检索中文数据库(CNKI、VIP、CBM、万方数据)及英文数据库(Medline、Cochrane Library)。主要结局指标:外周血象HGB、RBC、HCT及KPS评分。按照Cochrane偏倚风险表方法评价纳入文献质量,应用Cochrane协作网提供的Rev Man(Review Manager)v5.3统计软件进行统计资料分析。结果:纳入19个病例对照试验,共纳入患者1244例,汇总分析显示中医药的介入不仅能够在一定程度上使肿瘤相关性贫血患者的HGB水平、RBC水平、HCT水平等实验室指标得以提升(P<0.05),还可使肿瘤相关性贫血患者的生活质量KPS评分得以提升(P<0.05),进而提升总体治疗的有效率,改善肿瘤患者的体能和精神状况。结论:中医药一定程度上在肿瘤相关性贫血方面具有疗效,但还需进一步开展高质量的试验加以证实。

Objective To confirm the curative effect of traditional chinese medicine in the treatment of cancer-related anemia, and to provide more scientific and objective basis for research of cancer-related anemia. Methods The research object was published in the treatment of chinese medicine correlation of malignancy anemia as the observation group, with no partici-pation in cancer-related anemia treatment of traditional chinese medicine as control group in randomized con-trolled research literature from 2010 to 2014. By the method of full text retrieval, chinese retrieval words includ-ed anemia, tumor, cancer, traditional chinese medicine, chinese medicine, etc. The Electronic retrieval database was CNKI, WANFANG, VIP and Pubmed database. Main outcome indicators were： peripheral blood like HGB、RBC、RCT and KPS scores. According to the Cochrane faced method evaluation, literature quality and extrac-tion of available data were included. The RevMan （Review Manager） v5.3 statistical software supplied by Co-chrane net was used to finish the statistical data analysis. Results Total 19 cases of controlled trials were re-trieved, including 1244 cases of patients. The results showed that the intervention of chinese medicine could not only improve the HGB level, RBC level and HCT level in patients with cancer-related anemia to a certain ex-tent （P〈0.05）, but also can improve the quality of surxival,improve patients of KPS score （P〈0.05）, and then improve the overall treatment of the effective rate and improve the physical and mental status of cancer patients. Conclusion The intervention of chinese medicine has curative effect to a certain extent in treatment of can-cer-related anemia. The result needs to be further confirmed by high quality tests.