IMP3在卵巢原发性及转移性黏液腺癌中的表达及意义

The Expression and Significance of Oncogene IMP3 in Primary and Metastatic Ovarian Mucinous Carcinoma

目的癌基因IMP3在恶性肿瘤中异常高表达并可促进恶性肿瘤进展,但其在卵巢黏液腺癌中的表达及临床意义目前尚不明确,旨在探讨IMP3在卵巢原发性及转移性黏液腺癌中的表达及临床应用价值。方法收集2012—2017年复旦大学附属妇产科医院病理科诊断的卵巢黏液腺癌56例,其中原发性25例,转移性31例。免疫组化法检测卵巢组织中IMP3表达,分析IMP3表达与卵巢黏液腺癌临床病理参数的关系。结果卵巢黏液腺癌中,IMP3表达与肿瘤性质(原发/转移)、累及卵巢(单侧/双侧)、FIGO分期、是否累及输卵管、是否累及子宫、大网膜和阑尾及淋巴结转移显著相关(P<0.05)。结论 IMP3可用于卵巢原发性和转移性黏液腺癌的鉴别诊断,是肿瘤进展的一个判别辅助指标。

OBJECTIVE The oncogene IMP3 is reported to abnormally expressed in the somatic malignancies, promoting tumor progression. But the expression and application value of IMP3 in the primary and metastatic ovarian mucinous carcinomas were not certain. The study was aimed to analyze the clinical application of oncogene IMP3 in ovarian primary and metastatic mucinous carcinoma. METHODS We collected 56 cases of ovarian primary and metastatic mucinous carcinoma during 2012 to 20i7 in Gynecology and Obstetrics Hospital of Fudan University, 25 out of 56 cases were ovarian primary mucinous carcinoma, and 31 were metastatic carci- noma from other tissue origins. Then we collected the clinicopathological information and performed the immunochemistry. RESULTS The expression rate and intensity of IMP3 were much higher in metastatic cases than those in primary ones （P〈0.05）. The expression rate and intensity of IMP3 were much higher in cases with bilateral ovaries involved than those in cases with single lateral involved （P〈0.05）. The expression rate and intensity of IMP3 were much higher in cases with involved FIGO staging, fallopian tubes, uterine, omentum, appendix and lymph node metastasis than those in case without involvement（P〈0.05）. CONCLUSIONS IMP3 expression is higher in ovarian metastatic than primary mucinous carcinoma. IMP3 could be used in differential diagnosis and in monitoring the tumor progression in ovarian mucinous carcinoma.