摘要
由于眼表面和眼内结构的解剖、生理屏障作用,常规眼部制剂一般无法到达特定位置发挥作用。纳米材料由于尺寸小、易制备、可降解、靶向性强以及对生物组织刺激性小等特点,不同类型的纳米材料在运载不同化学特性药物方面优势明显。目前,纳米材料作为药物传输载体在眼部给药方面应用越来越多,并被用于各种类型眼部疾病的治疗,显示出良好的应用前景。本文就纳米材料作为药物传输载体在眼科疾病治疗方面的应用作一综述。
In view of the anatomical and physiological barrier of the ocular surface and the intraocular structure, the conventional ophthalmic agents cannot efficiently reach the lesion site. Currently, the different types of nanomaterials possess great advantages in delivering drugs due to their characteristics of small size, easy preparation, degradability, strong targeting and less irritation to biological tissue. As drug delivery carriers, nanomaterials have been widely used in ocular drug delivery so as to treat different types of eye diseases. In this paper, the applications of nanomaterials as drug delivery carriers in treating eye diseases are briefly reviewed.
作者
孙园园
郭大东
李少玉
陈美清
刘滨
毕宏生
Yuan-Yuan Sun Da-Dong Guo Shao-Yu Li Mei-Qing Chen Bin LiuI Hong-Sheng Bi(The Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China)
出处
《国际眼科杂志》
CAS
2017年第9期1671-1673,共3页
International Eye Science
基金
国家自然科学基金(No.81373826)
山东医药卫生科技发展计划(No.2013WS0251)~~
关键词
纳米材料
药物传输载体
眼病
nanomaterials
drug delivery carrier
eye diseases
