高脂血症性急性胰腺炎诊断中检测C反应蛋白、降钙素原的临床意义

Clinical Significance of Detection of C Reactive Protein and Calcitonin in the Diagnosis of Hyperlipidemia Acute Pancreatitis

目的探究高脂血症性急性胰腺炎诊断中检测C反应蛋白、降钙素原的临床意义。方法抽取2014年4月—2016年6月该院收治的72例高脂血症性急性胰腺炎患者,依据Ranson标准及CT分级将其分为重症组(n=37)与轻症组(n=35),另选取同期体检健康者37名作对照组。所有研究对象均于入院时、入院后4、8 h及12 h时抽取4.0 m L空腹外周静脉血送检。通过SPSS 19.0统计学软件对数据进行分析,对比不同时间段各组降钙素原及C反应蛋白、血清淀粉酶水平。结果重症组与轻症组入院后C反应蛋白与降钙素原水平整体呈上升趋势,血淀粉酶水平呈下降趋势,重症组、轻症组入院后4、8、12 h C反应蛋白[(114.13±41.56)、(123.12±41.05)、(159.73±41.42)mg/m L]、[(78.14±34.02)、(79.13±30.07)、(94.51±31.44)mg/m L]、降钙素原[(1.88±0.46)、(2.15±0.26)、(2.85±0.36)ng/m L]、[(0.29±0.10)、(0.58±0.15)、(0.58±0.25)ng/m L]、血淀粉酶[(1 000.62±738.51)、(733.61±506.62)、(729.50±498.73)ng/m L]、[(664.23±361.43)、(408.81±206.07)、(399.77±201.53)ng/m L]与对照组对比差异有统计学意义(P<0.05)。结论高脂血症性急性胰腺炎患者C反应蛋白及降钙素原水平表达异常,联合检测可及早确诊并鉴别病情严重程度,为治疗方案的制定提供指导依据,值得推广应用。

Objective To investigate the clinical significance of detection of C reactive protein and calcitonin in the di- agnosis of hyperlipidemia acute pancreatitis. Methods 72 patients with hyperlipidemia were selected in our hospital from April 2014 to June 2016.According to Ranson criteria and CT classification, they were divided into severe group （n=37） and mild group （n=35）, another 37 eases were selected as the control group. All of the subjects were on admis- sion and after admission of 4, 8h and 12h from 4.0mL fasting peripheral venous blood. The data were analyzed by SPSS19.0, and the levels of serum amylase and C reactive protein and serum amylase were compared in different time periods. Results The C reactive protein and the level of serum calcium were increased in the severe group and the mild group, and the serum amylase level was decreased.Severe group and mild group were 4,8,12 h C reaction protein [（114.13±41.56）,（123.12±41.05）, （159.73±41.42） mg/mL], [（78.14±34.02）, （79.13 ±30.07）, （94.51 ±31.44） mg/mL], calci- tonin original [（1.88±0.46）, （2.15± 0.26）, （2.85± 0.36） ng/mL], [（0.29 ±0.10）, （0.58 ± 0.15）, （0.58 ±0.25） ng/mL], The blood amylase [（1 000.62 ±738.51）, （733.61 ±506.62）, （729.50±498.73） ng/mL], [（664.23 ±361.43）, （408.81 ±206.07）, （399.77±201.53） ng/mL] comparing with the control group, the differences were statistically significant （P〈0.05）. Condu-sion C reactive protein and the level of serum calcium in patients with acute pancreatitis were abnormal, combined de- tection can be early diagnosis and identification of disease severity, to provide guidance for the development of treat- ment programs, it is worth promoting the application.