米力农对老年性顽固性心力衰竭患者心脏功能及N-末端脑钠肽前体水平的影响

Effect of milrinone on the cardiac function and N-terminal pro-brain natriuretic peptide levels in patients with senile refractory heart failure

目的:探讨米力农对老年性顽固性心力衰竭患者心脏功能及N-末端脑钠肽前体(NT-proBNP)水平的影响。方法:收集在本院接受治疗的老年性顽固性心力衰竭患者90例,随机分为对照组、观察组各45例。对照组接受临床常规治疗,观察组接受常规+米力农治疗。对比两组治疗前后心功能及血清NT-proBNP含量的差异。结果:治疗前,两组超声及血清心功能指标、血清NT-proBNP水平的差异无统计学意义(P>0.05)。治疗后,观察组超声心功能参数LVEDD的水平低于对照组,CI、SV的水平高于对照组患者;血清心功能指标Cys-C、GDF-15、sST2、H-FABP的含量低于对照组患者;血清中NTproBNP的含量低于对照组患者(P<0.05)。结论:老年性顽固性心力衰竭患者接受米力农治疗,可有效优化心脏功能并降低血清NT-proBNP水平。

Objective：To study the effect of milrinone on the cardiac function and N-terminal pro-brain natriuretic peptide（NT-proBNP）levels in patients with senile refractory heart failure.Methods：A total of 90 patients with senile refractory heart failure who were treated in our hospital between August 2013 and August 2016 were collected and divided into control group（n=45）and observation group（n=45）according to the random number table.The control group received regular clinical treatment,and the observation group received regular＋ milrinone treatment.The cardiac function and serum NT-proBN contents were compared between two groups of patients before and after treatment.Results：Before treatment,the differences in ultrasound and serum cardiac function indexes and serum NT-proBN levels were not statistically significant between two groups of patients（P〉0.05）.After treatment,ultrasound serum cardiac function parameter LVEDD level in observation group was lower than that in control group while CI and SV levels were higher than those in control group;serum cardiac function indexes Cys-C,GDF-15,sST2 and H-FABP contents were lower than those in control group;serum NT-proBNP content was lower than that in control group（P〈0.05）.Conclusions：Milrinone therapy can optimize the cardiac function and reduce the serum NT-proBN levels in patients with senile refractory heart failure.