mNGF注射液联合维生素D、甲钴胺对糖尿病周围神经病变患者神经功能及氧化应激的影响

Effect of mNGF injection combined with vitamin D and methylamine on neurological function and oxidative stress in patients with diabetic peripheral neuropathy

目的:探讨mNGF注射液联合维生素D、甲钴胺对糖尿病周围神经病变患者神经功能及氧化应激的影响。方法:收集本院收治的糖尿病周围神经病变患者120例,随机分为对照组、观察组各60例,对照组接受维生素D、甲钴胺治疗,观察组接受mNGF注射液联合维生素D、甲钴胺治疗,均持续8周。对比两组治疗前后的肌电图指标、神经功能指标、氧化应激指标的差异。结果:治疗前,两组的肌电图指标、神经功能指标、氧化应激指标差异无统计学意义(P>0.05)。治疗后,观察组的正中神经、尺神经、胫神经的MCV、SCV水平高于对照组患者;血清中神经功能指标BDNF、IGF-1的含量高于对照组患者,MBP的含量低于对照组患者;血清中氧化应激指标SOD、GSH、T-AOC的含量高于对照组,MDA、AOPP的含量低于对照组(P<0.05)。结论:mNGF注射液联合维生素D、甲钴胺可优化DPN患者的肌电图及神经功能,降低全身氧化应激反应。

Objective：To study the effect of mNGF injection combined with vitamin D and methylamine on neurological function and oxidative stress in patients with diabetic peripheral neuropathy.Methods：A total of 120 patients with diabetic peripheral neuropathy who were treated in our hospital between July 2012 and February 2016 were collected and randomly divided into control group（n=60）and observation group（n=60）,control group were treated with vitamin D and methylamine,observation group received mNGF injection combined with vitamin D and methylamine therapy,and both therapies lasted for 8weeks.Electromyography indexes,neurological function indexes and oxidative stress indexes were compared between two groups of patients before and after treatment.Results：：Before treatment,the differences in electromyography indexes,neurological function indexes and oxidative stress indexes were not statistically significant between two groups of patients（P〉0.05）.After treatment,the MCV and SCV levels of median nerve,ulnar nerve and tibial nerve in observation group were significantly higher than those in control group;serum neurological function indexes BDNF and IGF-1contents were significantly higher than those in control group while MBP content was significantly lower than that in control group;serum oxidative stress indexes SOD,GSH and T-AOC contents were significantly higher than those in control group while MDA and AOPP contents were significantly lower than those in control group（P〈0.05）.Conclusions：mNGF injection combined with vitamin D and methylamine can optimize the electromyography and neurological function,and reduce the systemic oxidation stress response in patients with DPN.