上感颗粒对肺炎链球菌感染性肺炎小鼠白细胞、C反应蛋白和肺指数的影响

Effects of Shanggan Granule on White Blood Cell,CRP and Lung Index in Mice with Streptococcus Pneumoniae

目的观察上感颗粒对肺炎链球菌感染性肺炎小鼠白细胞、C反应蛋白(CRP)和肺指数的影响,探讨该方是否对肺炎链球菌感染性肺炎小鼠具有治疗作用。方法肺炎链球菌感染性肺炎小鼠随机分正常组、模型组、上感颗粒低剂量组、上感颗粒高剂量组、盐酸左氧氟沙星组、上感颗粒高剂量联合盐酸左氧氟沙星组,观察给药第3日末、第6日末其白细胞、CRP和肺指数水平的变化。结果上感颗粒低剂量组、高剂量组、上感颗粒高剂量联合盐酸左氧氟沙星组均能降低肺炎链球菌感染性肺炎小鼠的肺指数、血白细胞、CRP水平,与模型组比较差异有统计学意义(P<0.05)。结论上感颗粒可降低肺炎链球菌感染性肺炎小鼠的肺指数、血白细胞、CRP水平,表明其对肺炎链球菌感染性肺炎小鼠有治疗作用。

Objective： To observe effects of Shanggan Granule on white blood cell,CRP and lung index in mice with streptococcus pneumonia, and to investigate whether the prescription has therapeutic effect on streptococcus pneumoniae infected mice. Methods： Streptococcus pneumoniae infected mice were randomly divided into 6 groups： the normal group,the model group,low dose group of Shanggan Granule,high dose group of Shanggan Granule,Levofioxacin group and the group of high dose of Shanggan Granule and Levofloxacin. White blood cell, CRP and lung index were observed on 3rd and 6th day after treatment. Results： Compared with the model group, the degree of white blood cell,CRP and lung index in low dose group of Shanggan Granule,high dose group of Shanggan Granule and the group of high dose of Shanggan Granule and Levofloxacin significantly reduced （P 〈 0.05）. Conclusions： Shanggan Granule can reduce white blood cell, CRP and lung index in mice with streptococ- cus pneumoniae,which shows that it has a therapeutic effect on streptococcus pneumoniae infected mice.