改善全麻药发育期神经毒性的研究进展

Progress of ameliorating the neurotoxicity of anaesthetics on developing brain

全麻药在孕、产妇及婴幼儿的应用非常广泛。有关啮齿类、哺乳类及非人灵长类的基础研究表明,全麻药可对发育中大脑产生神经毒性,造成神经细胞凋亡和神经发育受损。因此,探究改善全麻药发育期神经毒性的措施及机制对于制定临床麻醉方案,指导产科及儿科麻醉具有重要意义。本文主要综述近年来改善全麻药发育期神经毒性的研究进展,涉及的措施包括应用麻醉辅助药、内分泌激素类药物、植物提取物及营养类物质等。

General anesthetics are widely used in pregnant women,gravidas and infants. In the basic studies of rodents, mammals and non-human primate, general anesthetics can cause neurotoxicity, neuroapoptosis and damage neurodevelopment on the developing brain. Therefore, To explore protective measures and mechanism of anesthetic neurotoxicity is of great significance for formulating clinical anesthesia plan, guiding clinical obstetrics and pediatric anesthesia. This article reviewed the progress of ameliorating the neurotoxicity of general anaesthetics on developing brain including anesthetic assistants, hormone drugs, plant extracts, nutritional components and others.