微小核糖核酸在白塞病发病中的作用及其临床应用前景

The pathgenetic role and potential clinical application of miRNAs in patients with Behcet's disease

微小核糖核酸(miRNA)是核糖核酸干扰的内源性介质,通过诱导转录后靶基因表达沉默发挥生物学作用。miRNA对机体免疫细胞具有多种调控功能,参与固有免疫和适应性免疫的调节。异常表达的miRNA通过调节免疫细胞炎性因子参与白塞病(Behcet’s disease,BD)的发病,可能成为BD诊断的标志物和治疗靶点。本文从miRNA调节自身免疫,部分miRNA参与BD发病的机制,miRNA潜在的临床应用价值等进行综述。

As the endogenous mediators of RNA interference, miRNA play biological roles by inducing post-transcriptional silence of gene expression. Previous studies showed that miRNAs have multiple regulating potential to immune cells, involved in regulation of innate and adaptive immunity. Recently,aberrant expression of miRNAs have been confirmed to be relevant to the pathogenesis of Behcet＇s disease （BD） by regulating the expression of inflammatory cytokines in immune cells, which may become of its diagnostic marker and therapeutic target in the future. In this review,we discuss how miRNAs regulate autoimmunity, Several miRNAs associate with the pathogenesis of BD, thus they have the potential clinical application value.