H型高血压与急性冠脉综合征及同型半胱氨酸水平的相关性研究

Study of the correlation between H-type hypertension and acute coronary syndrome and the level of Hcy

目的探讨H型高血压与急性冠脉综合征(ACS)及同型半胱氨酸(Hcy)水平的相关性。方法将我院收治的166例原发性高血压合并冠心病患者根据Hcy水平分为研究组与对照组,各83例。研究组为H型高血压患者(Hcy≥10μmol/L),对照组为原发性高血压患者(Hcy<10μmol/L)。比较两组ACS发生率和冠脉病变积分,记录患者的Hcy、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清总胆固醇(TC)水平。结果研究组的ACS发生率和冠脉病变积分均高于对照组(P<0.05)。研究组ACS患者血清Hcy水平高于非ACS患者(P<0.05),ACS和非ACS患者的LDL-C、HDL-C及TC值比较,差异无统计学意义(P>0.05)。对照组ACS患者血清Hcy水平低于非ACS患者,LDL-C、TC值高于非ACS患者,差异均有统计学意义(P<0.05);对照组ACS患者与非ACS患者HDL-C值比较,差异无统计学意义(P>0.05)。结论 H型高血压与ACS的发病密切相关,原发性高血压患者Hcy水平的升高会促使ACS的发生,H型高血压的有效控制对预防ACS具有重要意义。

Objective To investigate the correlation between H-type hypertension and acute coronary syndrome （ACS） and the level of homocysteine （Hcy）. Methods A total of 166 patients with essential hypertension and coronary heart disease in our hospital were selected and divided into study group and control group according to the Hcy level, with 83 cases in each group. There were 83 patients with H -type hypertension in the study group （Hcy ≥10 μmol/L） and 83 patients with primary hypertension in the control group （Hcy〈10 μmol/L）. The incidence of ACS and coronary lesion score were compared between the two groups, and the levels of Hcy, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C） and serum total cholesterol （TC） were recorded. Results The incidence rate of ACS and coronary lesion score in the study group were higher than those in the control group （P〈0.05）. In the study group, the serum Hcy level of patients with ACS was higher than that of non-ACS patients （P〈0.05）; there was no significant differences in LDL-C, HDL-C and TC levels between patients with ACS and non-ACS （P〉0.05）. In the control group, the serum Hcy level of patients with ACS was lower than that of non-ACS patients, LDL-C and TC levels of patients with ACS were higher than those of non-ACS patients （P〈0.05）, and there was no difference in HDL-C level between patients with ACS and non-ACS in the control group （P〉0.05）. Conclusion H-type hypertension is closely related to ACS, the high Hcy level in patients with essential hypertension will lead to the occurrence of ACS. The effective control of H-type hypertension is important for preventing the occurrence of ACS.