盐酸伊托必利联合黛力新治疗功能性消化不良的临床效果

Clinical effect of itopride hydrochloride combined with Deanxit in the treatment of functional dyspepsia

目的探讨盐酸伊托必利联合黛力新治疗功能性消化不良患者的效果。方法选取在我院就诊的功能性消化不良患者90例,随机分为观察组和对照组,每组45例。对照组给予黛力新治疗,观察组给予盐酸伊托必利联合黛力新治疗,对比分析两组患者治疗前、后的胃电功率、胃电节律及血清SS和5-HT水平。结果治疗前,两组患者胃窦、胃小弯、胃体及胃大弯的电功率和电节律以及血清SS和5-HT水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者胃窦、胃小弯、胃体及胃大弯的电功率和电节律均低于治疗前和对照组(P<0.05),对照组患者胃窦、胃小弯、胃体及胃大弯的电功率和电节律与治疗前比较,差异不显著(P>0.05)。治疗后,两组患者的血清SS和5-HT水平均低于治疗前,观察组的均显著低于对照组(P<0.05)。结论盐酸伊托必利联合黛力新治疗功能性消化不良效果显著,可明显改善患者的胃肠道功能,值得在临床上广泛应用。

Objective To investigate the effects of itopride hydrochloride combined with Deanxit in the treatment of functional dyspepsia （FD）. Methods Ninety cases of FD patients in our hospital were randomly divided into control group and observation group, with 45 cases in each group. Patients in the control group were treated with Deanxit, while patients in the observation group were treated with itoprlde hydrochloride combined with Deanxit. The gastric electric power, gastric electric rhythm, levels of serum SS and 5-HT were compared between the two groups before and after treatment. Results Before treatment, there were no significant differences in gastric electric power, gastric electric rhythm, levels of serum SS and 5-HT between the two groups （P〉0.05）. After treatment, the electrical power and electrical rhythm of the gastric antrum, lesser gastric curvature, gastric body and greater curvature in the observation group were lower than those before treatment and those of the control group （P〈0.05）; there were no significant differences in the electrical power and electrical rhythm of the gastric antrum, lesser gastric curvature, gastric body and greater curvature in the control group before and after treatment （P〉0.05）. After treatment, the serum SS and 5-HT levels of the two groups were lower than those before treatment, and the serum SS and 5-HT levels of the observation group were significantly lower than those of the control group （P〈0.05）. Conclusion Itopride hydrochloride combined with Deanxit has significant curative effects in FD, which can obviously improve gastroenteric function of the patients, and it is worthy of clinical application.