麝香保心丸长期治疗老年不稳定性心绞痛的疗效及耐受性观察

Long term efficacy and tolerability of Shexiang Baoxin pills in the treatment of unstable angina pectoris in the elderly

目的研究麝香保心丸长期治疗老年不稳定性心绞痛的疗效及安全性。方法将我院76例老年不稳定心绞痛患者随机分为观察组(38例)、对照组(38例),均接受常规治疗,观察组另口服麝香保心丸12个月,比较两组患者治疗1年后的临床疗效,治疗前、后的Hcy、Hs-CRP水平,心脏事件发生率及不良反应发生情况。结果观察组临床总有效率明显高于对照组(P<0.05);观察组治疗后6、12个月的Hcy水平显著低于对照组,12个月Hs-CRP水平显著低于对照组(P<0.05);观察组心绞痛再入院率显著低于对照组(P<0.05);两组不良反应发生率比较,差异不明显(P>0.05)。结论麝香保心丸长期治疗老年不稳定性心绞痛疗效显著,可有效降低Hcy、Hs-CRP水平,降低远期心脏事件发生风险且耐受性良好,临床价值高。

Objective To study the efficacy and safety of Shexiang Baoxin pills in the treatment of unstable angina pectoris in the elderly. Methods Seventy-six elderly patients with unstable angina pectoris in our hospital were randomly divided into observation group （38 cases） and control group （38 cases）. All the patients received conventional treatment, the observation group was treated with Shexiang Baoxin pills on the basis of conventional treatment for 12 months. The effects of after 1 year＇s treatment, the levels of Hcy and Hs-CRP before and after treatment; the incidence of cardiac events and adverse reactions in the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group （P〈0.05）. The level of Hcy in the observation group after treatment for 6 and 12 months were significantly lower than those in the control group （P〈0.05）, the level of Hs-CRP in the observation group after treatment for 12 months was significantly lower than that in the control group （P〈0.05）. The angina readmission rate in the observation group was significantly lower than that in the control group （P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P〉0.05）. Conclusion Shexiang Baoxin pills is effective in the treatment of unstable angina pectoris in elderly patients. It can effectively reduce the levels of Hcy and Hs-CRP, decrease the risk of long-term cardiac events, and have good tolerability. It has high clinical value.