正常人视神经高分辨MRI及多平面重建技术研究

The study of optic nerve in human using high resolution MRI with multiplanar reconstruction

目的探讨三维高分辨MRI扫描序列和多平面重建技术在正常人视神经成像的应用效果。方法前瞻性临床研究。对2014年6月至2015年6月在郑州大学第一附属医院眼科就诊的30例无视力障碍的健康成年志愿者行MRI检查，采用T1加权三维容积内插快速扰相梯度回波序列（3D-VIBE）和T2加权三维双回波稳态进动序列（3D-DESS）行眼部MRI扫描，应用多平面重建技术进行平行视神经的轴位和斜矢状位图像重建，观察视神经全程的显示情况，测量视神经全长，比较两种重建方法的差异。结果高分辨MRI在平行于视神经的轴位和斜矢状位重建图像上均能较好显示视神经全程及细微结构，轴位测量视神经全长为（43.48±3.30）mm，斜矢状位为（42.10±3.16）mm，轴位测量值大于斜矢状位（t=2.98，P〈0.01）。结论高分辨MRI联合多平面重建技术能够从不同方位清晰显示视神经整体轮廓，精确测量视神经长度，为视神经的解剖学研究及其病变的早期诊断提供可靠的客观依据。

Objective To evaluate the images of optic nerve in normal human volunteers using three-dimensional high resolution MRI and multiplanar reconstruction. Methods A total of 30 healthy volunteers underwent magnetic resonance imaging （MRI） with the sequences of 3D-VIBE and 3D-DESS. The axis and oblique sagittal images were obtained with multiplanar reconstruction. The quality of the images was analyzed, and the length of the optic nerve was measured on axis and oblique sagittal images. Results The anatomy of the optic nerve could be clearly displayed on both axial and oblique sagittal images. The full length of optic nerve was 43.48±2.60 mm on axial image and 42.10±3.16 mm on oblique sagittal image. The measured value of axial image was higher than that of oblique sagittal image （t =2.98, P 〈0.01）. Conclusions High resolution MRI with multiplanar reconstruction can visualize the fine structure of the optic nerve, and facilitate to measure the length of optic nerve, it can provide a reliable method for the study of the anatomy and diseases of optic nerve.