痰瘀同治方联合化疗治疗进展期胃癌术后60例临床观察

Clinical observation on 60 cases of postoperative patients with advanced gastric cancer treated with tanyu tongzhi fang combined with chemotherapy

[目的]观察痰瘀同治方联合化疗治疗进展期胃癌术后患者的临床疗效。[方法]将符合纳入标准的进展期胃癌术后患者,随机分为治疗组和对照组各30例。对照组单纯化疗,具体为:奥沙利铂注射液130mg/m2,第1天静脉滴注,同时口服替吉奥胶囊80mg/m2,第1天至第14天,21天为1个周期,共6个周期。随后单独口服替吉奥6个周期。治疗组在化疗的基础上联合痰瘀同治方为主的辨病辨证相结合中医治疗,每日1剂,连续服用2年。比较2者术后半年、1年、2年的复发转移率,无进展生存时间(PFS),及治疗前后中医证候评分、生活质量评分(Karnofsky),及化疗毒副反应发生情况。[结果]治疗组半年、1年、2年复发转移率分别为:6.67%、20%、30%,对照组分别为:6.67%、33.33%、56.67%,治疗组2年复发转移率低于对照组,差异有统计学意义(P<0.05)。治疗组的无进展生存时间(PFS)为28.1个月,对照组为21.1个月,2组比较差异有统计学意义(P<0.05)。治疗组中医证候评分和生活质量评分改善程度均优于对照组(P<0.05)。毒副反应中治疗组恶心呕吐反应较对照组轻,2组比较差异有统计学意义(P<0.05)。[结论]痰瘀同治方联合化疗能降低进展期胃癌术后患者的复发转移率,延长无进展生存时间,改善患者中医证候和生活质量,降低化疗毒副反应。

[Objective]To observe the clinical effects of Tanyu Tongzhi Fang combined with chemotherapy in the treatment of 60 postoperative patients with advanced gastric cancer.[Methods]The 60 patients were randomly divided into the control group（30cases）and the treatment group（30cases）.Both groups were given chemotherapy with oxaliplatin（130mg/m2,iv,d1）ans S-1（80mg/m2·d,oral,d1-14）.The regimen took 21 days as one cycle,and totally six cycles of treatment were given.After these six cycles,both groups were only given S-1（80mg/m2·d,oral,d1-14）.The regimen also took 21 days as one cycle,and totally six cycles of treatment were given.Meanwhile,patients in treatment group were treated with combination of treatment of Tanyu Tongzhi Fang based on syndrome differentiation.Half-year,1-year,2-year relapse metastatic rates in two groups were followed-up.Progression free survival time（PFS）,scores of chinese medical symptom and quality of life in two groups were compared.Toxic and side effects were evaluated after the treatment.[Results]2-year relapse metastatic rates in the treatment group were lower than those in the control group（P〈0.05）.PFS in the treatment group was better than that in the control group（P〈0.05）.Scores of chinese medical symptom,quality of life in the treatment group were better than inthe control group（P〈0.05）.In the adverse reactions,the incidence of nausea and vomiting in the treatment group was lower than that in the control group（P〈0.05）.[Conclusion]Tanyu Tongzhi Fang combined with chemotherapy can reduce relapse metastatic rates and prolong PFS time of postoperative patients with advanced gastric cancer.It also can improve chinese medical symptom,quality of life and reduce toxic and side effects of chemotherapy.