慢加急性肝衰竭:东西方诊断和预后的差异

Acute-on-chronic liver failure: Difference in definition and prognosis between the East and West

慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)是以慢性肝病基础上发生的急性肝功能失代偿和短期高死亡率为主要临床特征的一种可逆的、复杂的临床综合征.由于不同区域ACLF的病因不同,且病理机制复杂,导致东西方对ACLF的定义及诊断标准仍存在争议,且缺乏公认的预后评估体系.近年来,ACLF引起了国内外学者的广泛关注,取得了一些重要的研究进展,本文将围绕国际上ACLF的最新进展,对ACLF的定义及预后评估等进行分析总结.

Acute-on-chronic liver failure（ACLF） refers to a complex clinical syndrome with fast progression and high mortality. There is discrepancy between the East and West in the definition and diagnostic criteria for ACLF, and no uniform prognostic evaluation system is currently applicable, because of the different causes and the complexity of pathogenesis. In recent years, ACLF has attracted attention of scholars all over t he world, and some important progress has been made. This paper aims to make a summary of ACLF with regard to its definition and the prognostic evaluation system.