中老年男性代谢综合征与前列腺增生关系的研究

Relationship between metabolic syndrome and benign prostatic hyperplasia in elderly men

目的 探讨中老年男性人群中代谢综合征和前列腺增生（benign prostatic hyperplasia, BPH）的关系.方法 随机选择2015年5月至2016年2月本院体检中心体检的中老年男性350例作为研究对象.调查所有研究对象的一般情况,包括年龄、身高、体质量、血压、既往史、国际前列腺症状评分（IPSS）等;抽取空腹静脉血检测血糖、三酰甘油、高密度脂蛋白和前列腺特异性抗原（PSA）;腹部超声测量前列腺体积, 并检测Qmax.比较代谢综合征组和非代谢综合征组BPH患病率及严重程度.结果 代谢综合征组100例,合并BPH者30例（30%）;非代谢综合征组250例,合并BPH者35例（14%）.代谢综合征组的BPH患病率较高,与非代谢综合征组相比,代谢综合征组IPSS、前列腺体积和血清PSA值存在差异,差异有统计学意义（P〈0.05）,两组间Qmax差异无统计学意义（P=0.057）.结论 代谢综合征患者的BPH患病率较高,代谢综合征影响BPH患者的IPSS、前列腺体积和PSA.肥胖、高脂血症、高血压、空腹血糖高或糖尿病是BPH的危险因素.BPH患者诊疗的同时还需要考虑是否合并代谢综合征.

Objectives To explore the relationship between metabolic syndrome（MS） and benign prostatic hyperplasia（BPH） in elderly men.Methods From May 2015 to February 2016, 350 cases of elderly men in the medical examination center of our hospital were collected.Age,blood pressure, past history and the international prostate symptom score （IPSS） were recorded.Plasma glucose, triglyceride, high density lipoprotein, prostate specific antigen（PSA）,prostatic volume and Qmax were measured.The morbidity and severity of BPH were compared.Results Three hundred and fifty men were enrolled,and were divided into 2 groups：MS group（n=100） and non-MS group （n=250）.Compared with the non-MS group,the morbidity of BPH was higher in the MS group.There were significant differences in the IPSS,prostate volume and PSA between the MS and non-MS group（P〈0.05）,but there was no difference in Qmax between these two groups（P=0.057）.Conclusions There is higher morbidity of BPH in MS patient.MS can increase IPSS and prostate volume,and reduce PSA in BPH ptaiant.Obesity,hyperlipemia and diabetes mellitus are risk factors of BPH.MS should be considered when treating BPH.