硫酸镁联合拉贝洛尔治疗妊娠期高血压疾病临床疗效观察

Clinical effect of magnesium sulfate combined with labetalol in treatment of pregnancy-induced hypertension

目的研究分析硫酸镁联合拉贝洛尔治疗妊娠期高血压疾病临床疗效。方法选取我院于2016年1月至2016年10月收治的86例妊娠期高血压患者,将其随机分为观察组和对照组,观察组43例采用硫酸镁联合拉贝洛尔治疗,对照组43例采用硫酸镁治疗,对比两组患者治疗效果。结果观察组的治疗总有效率97.7%高于对照组81.4%,且母婴结局情况和剖腹产率均低于对照组,同时观察组治疗后SBP、DBP、MAP、HR的改善情况优于对照组,有统计学意义(P<0.05)。结论妊娠期高血压疾病采用硫酸镁联合拉贝洛尔治疗效果显著,可以改善患者的血压水平,改善母婴结局,值得临床推广。

Objective To investigate the clinical effect of magnesium sulfate combined with labetalol in the treatment of pregnancy-induced hypertension. Methods A total of 86 patients with pregnancy-induced hypertension who were admitted to our hospital from January to October, 2016 were enrolled and randomly divided into observation group and control group, with 43 patients in each group. The patients in the observation group were given magnesium sulfate combined with labetalol, and those in the control group were given magnesium sulfate alone. The treatment outcome was compared between the two groups. Results The observation group had a significantly higher overall response rate than the control group（97.7% vs 81.4%, P〈0.05）, and compared with the control group, the observation group had significantly better maternal and fetal outcomes, a significantly lower rate of cesarean delivery, and significantly better improvements in systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate（P〈0.05）. Conclusion Magnesium sulfate combined with labetalol has a marked clinical effect in the treatment of pregnancy-induced hypertension and can improve patients＇ blood pressure and maternal and fetal outcomes. Therefore, it holds promise for clinical application.