血栓抽吸联合替罗非班治疗急性前壁ST段抬高心肌梗死的临床效果观察

Clinical effect of thrombus aspiration combined with tirofiban in treatment of anterior wall ST-segment elevation acute myocardial infarction

目的探究急性前壁ST段抬高心肌梗死患者应用血栓抽吸联合替罗非班治疗的临床疗效。方法选择2015年6月至2016年12月在我院接受治疗的急性前壁ST段抬高心肌梗死患者80例作为临床研究对象,按照投掷硬币的方式将其随机分为对照组、观察组两组。对照组40例患者应用替罗非班治疗,观察组40例患者在对照组的基础上联合血栓抽吸治疗,比较所有患者术后各项临床指标情况。结果两组患者经不同治疗方法治疗后,对照组患者的左心射血分数值(42.01±5.88%)、左室舒张末径(48.55±9.11)mm以及NT-pro BNP值(540.44±30.51)pg/m L与观察组患者的左心射血分数值(52.23±4.11%)、左室舒张末径(44.88±3.58)mm以及NT-pro BNP值(310.67±25.19)pg/m L;观察组患者的六分钟试验结果(550.12±50.88)m与对照组患者的相比,差异均具有统计学意义(P<0.05)。结论应用血栓抽吸联合替罗非班治疗急性前壁ST段抬高心肌梗死患者,效果理想,安全性高,有效提高心功能,值得在临床上推广应用。

Objective To investigate the clinical effect of thrombus aspiration combined with tirofiban in the treatment of anterior wall ST-segment elevation acute myocardial infarction. Methods A total of 80 patients with anterior wall ST-segment elevation acute myocardial infarction who were treated in our hospital from June 2015 to December 2016 were enrolled and randomly divided into control group and observation group using coin tossing, with 40 patients in each group. The patients in the control group were given tirofiban, and those in the observation group were given tirofiban combined with thrombus aspiration. The clinical indices after treatment were compared between the two groups. Results After treatment, there were significant differences between the observation group and the control group in left ventricular ejection fraction（52.23%±4.11% vs 42.01%±5.88%, P〈0.05）, left ventricular end-diastolic diameter（44.88 ±3.58 mm vs 48.55 ±9.11 mm, P〈0.05）, N-terminal pro-brain natriuretic peptide level（310.67 ±25.19 pg/ml vs540.44 ±30.51 pg/ml, P〈0.05）, and 6-minute walking test result（550.12 ±50.88 m vs 465.23 ±72.36, P〈0.05）.Conclusion Thrombus aspiration combined with tirofiban has a good clinical effect and high safety in the treatment of anterior wall ST-segment elevation acute myocardial infarction and can effectively improve cardiac function. Therefore, it holds promise for clinical application.