小剂量甲状腺素治疗早产儿暂时性甲状腺功能低下临床效果及安全性

The clinical efficacy and safety observation of low dose LT_4 in the treatment of preterm infants with transient hypothyroidism

目的观察小剂量甲状腺素(LT_4)治疗早产儿暂时性甲状腺功能低下的临床效果及安全性。方法将暂时性甲状腺功能低下早产患儿120例采用随机数字表法分为观察组和对照组各60例。对照组采用常规治疗,观察组在对照组基础上加用小剂量LT_4治疗,比较2组患儿的各项临床指标和治疗前后甲状腺激素水平。结果治疗后2组患儿的体质量增加、新生儿神经行为测定(NBNA)评分比较无统计学意义(P>0.05);观察组静脉营养时间、黄疸持续时间、喂养不耐受持续时间短于对照组,差异均有统计学意义(P<0.05);观察组患儿的游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)高于对照组,促甲状腺素(TSH)低于对照组,差异均有统计学意义(P<0.05)。结论小剂量LT_4治疗暂时性甲状腺功能低下早产患儿,能显著促进患儿临床症状的改善,提高治疗效果。

Objective To analysis the low dose of thyroXine（LT4） clinical efficacy and safety of treatment of premature infants with hypothyroidism.Methods 120 case of patients with transient hypothyroidism were randomly divided into observation group and control group,each group of 60 cases.The control group was treated with conventional treatment,the observation group was treated with low dose LT4,compared the two groups of children in the clinical indicators and thyroid hormone levels before and after treatment.Results After treatment,the weight growth and NBNA score of two groups were no statistically significant（P〉0.05）;The intravenous nutrition time,jaundice duration in patients with feeding intolerance,time duration time were shorter than the control group（P〈0.05）;The FT3,FT4 of patients in the observation group were higher than the control group,TSH was lower than the control group（P〈0.05）.Conclusion Low dose of LT4 in the treatment of children with temporary hypothyroidism can significantly improve the clinical symptoms and the quality of treatment.