复方聚乙二醇电解质散联合腹部按摩预防肺癌患者顺铂化疗所致便秘的效果研究

Preventive Effect of Compound Polyethylene Glycol Electrolyte Powder Combined with Abdominal Massage on Cisplatin-induced Constipation of Lung Cancer Patients

目的探索复方聚乙二醇电解质散联合腹部按摩预防肺癌患者顺铂化疗所致便秘的临床效果。方法选择2016年7月~10月我院收治的120例肺癌顺铂化疗患者,将其随机分成对照组和观察组,每组60例。对照组采用常规预防方法。观察组在常规方法的基础上,于化疗前1天预防性口服聚乙二醇电解质散1次,从化疗当天开始每天口服聚乙二醇电解质散,每天2次,连续服用3天;从化疗当天开始每天进行腹部按摩,连续5天。参照美国国家癌症研究所常见不良反应事件评价标准(CTCAE)4.0版,记录化疗当天至化疗后第7天患者的便秘发生率、便秘分级及灌肠次数。结果观察组和对照组的便秘发生率分别为8.33%和26.67%,2级及以上便秘发生率分别为1.67%和13.33%,观察组均显著低于对照组(P<0.05)。此外,观察组灌肠率明显低于对照组(P<0.05)。结论复方聚乙二醇电解质散联合腹部按摩预防肺癌患者顺铂化疗所致便秘的临床效果好。

Objective To explore the preventive effect of compound polyethylene glycol electrolyte powder combined with abdominal massage on the cisplatin-induced constipation of lung cancer patients. Methods Between July and October in 2016, 120 cases of lung cancer patients treated with cisplatin chemotherapy were randomly divided into two groups, 60 cases in each group. Patients in the control group were treated with the conventional prevention method. While those in the observation group were treated with compound polyethyl- ene glycol electrolyte powder combined with abdominal massage on the base of conventional prevention. They got oral polyethylene glycol electrolyte powder once at the day before chemotherapy, and twice from the first day to the third day of chemotherapy. Meanwhile, they got abdominal massage from the first day of chemotherapy, lasting for five consecutive days. According to the National Cancer Institute Common Adverse Events evaluation criteria （CTCAE） （4.03 edition）, the incidence of constipation were recorded from the first day of chemotherapy to the seventh day after chemotherapy. The classification of constipation and the times of enema were also valued as main events. Results The incidence of constipation in the observation group and the control group was 8.33% and 26.67%, respectively. The incidence of constipation at grade 2 and over was 1.67% and 13.33% respectively in the observation group and the control group, and it was significantly lower in the observation group than in the control group （P〈0.05）. Besides, the times of enema in the observation group was significantly less than in the control group and the difference was statistically significant （P 〈 0.05）. Conclusion Compound polyethylene glycol electrolyte powder com- bined with abdominal massage is effective in the prevention of constipation in cisplatin-treated lung cancer.