小剂量多巴胺联合呋塞米治疗心力衰竭的临床疗效

Clinical effect of small doses of dopamine combined with furosemide in the treatment of heart failure

目的探讨小剂量多巴胺联合呋塞米治疗心力衰竭的临床疗效。方法选取四川友谊医院2015年2月—2016年10月收治的心力衰竭患者90例,根据治疗方案不同将患者分为对照组与治疗组,各45例。对照组患者予以呋塞米治疗,治疗组患者在对照组治疗基础上予以小剂量多巴胺治疗,两组患者均连续治疗2周。比较两组患者临床疗效、心功能指标[心率(HR)、收缩压(SBP)、舒张压(DBP)、左心室射血分数(LVEF)、B型尿钠肽(BNP)]及不良反应发生情况。结果治疗组患者临床疗效优于对照组(P<0.05)。治疗组患者HR、SBP、DBP、BNP水平低于对照组,LVEF高于对照组(P<0.05)。两组患者均未发生严重不良反应。结论小剂量多巴胺联合呋塞米治疗心力衰竭的临床疗效确切,可有效改善患者心功能,缓解水钠潴留等症状。

Objective To investigate the clinical effect of small doses of dopamine combined with furosemide in the treatment of heart failure. Methods A total of 90 cases of heart failure patients were selected from February 2015 to October2016 in Sichuan Friendship Hospital,which were divided into control group and treatment group according to different treatments,45 cases in each group. Control group was given furosemide,treatment group was treated with small doses of dopamine based on control group,both groups were treated for 2 weeks. The clinical effect,cardiac function indexes（ HR,SBP,DBP,LVEF,BNP） and the incidence of adverse reactions were compared between the two groups. Results The clinical effect of treatment group was better than control group（ P〈0. 05）. The treatment group of HR,SBP,DBP,BNP levels were lower than control group,LVEF was higher than control group（ P〈0. 05）. There were no serious adverse reactions happened. Conclusion Small doses of dopamine combined with furosemide have an exactly clinical effect in the treatment of heart failure,it can effectively improve the cardiac function,and alleviate symptoms such as retention of water and sodium.