放化疗治疗活动性肺结核合并肺部肿瘤的临床疗效

Clinical effect of chemoradiotherapy in treating active pulmonary tuberculosis combined with lung neoplasms

目的探讨放化疗治疗活动性肺结核合并肺部肿瘤的临床疗效。方法选取石家庄市第一人民医院2012年6月—2014年4月收治的活动性肺结核合并肺部肿瘤患者98例,根据不同的治疗方案分为A组52例和B组46例。患者入院后均给予抗结核药物治疗,A组患者采用常规营养支持治疗,B组患者给予放、化疗。比较两组患者的临床疗效、治疗前后生活质量评分及毒副作用[碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)异常]。结果 B组患者临床疗效优于A组(P<0.05)。治疗前,两组患者生活质量评分比较,差异无统计学意义(P>0.05);治疗后,B组患者生活质量评分高于A组(P<0.05)。B组患者治疗期间ALP、ALT、AST水平高于A组(P<0.05)。结论采用放化疗治疗活动性肺结核合并肺部肿瘤的临床疗效确切,可有效提高患者的远期生活质量,但易增加毒副作用,需谨慎使用。

Objective To explore the clinical effect of chemoradiotherapy in treating active pulmonary tuberculosis combined with lung neoplasms. Methods A total of 98 cases of patients with active pulmonary tuberculosis combined with lung neoplasms were selected from June 2012 to April 2014 in the First People＇s Hospital of Shijiazhuang City,which were divided into A group（ n = 52） and B group（ n = 46）. All patients were treated with antituberculosis drugs,A group was given conventional nutritional support treatment,B group was given chemoradiotherapy. The clinical effect,the quality of life before and after treatment,toxic and side effects（ ALP,ALT,AST） were compared between the two groups. Results The clinical effect of B group was better than A group（ P〈0. 05）. Before treatment,no statistically significant difference of score of the quality of life was found between the two group（ P〉0. 05）; after treatment,the B group of score of the quality of life was higher than A group（ P〈0. 05）. The B group of ALP,ALT,AST levels were higher than A group（ P〈0. 05）. Conclusion Chemoradiotherapy has an exactly clinical effect in treating active pulmonary tuberculosis combined with lung neoplasms,it can effectively promote the long-term quality of life,but with more toxic and side effects,so need to be used with caution.