结直肠癌组织中NF-E1b的表达及其与患者临床病理特征和预后的关系

Expression of NF-E1b in colorectal cancer tissues and its relationship with clinical and pathological features and prognosis of colorectal cancer

目的分析结直肠癌患者癌组织NF-E1b的表达情况与临床病理特征及预后的关系。方法选择2010年4月至2013年4月于本院行结直肠癌根治术的129例患者作为研究对象,采用免疫组化法检测患者癌组织及癌旁组织中NF-E1b的表达情况,收集患者临床资料并进行3年随访,分析NF-E1b表达情况与患者病理特征的关系及与3年生存率的影响。结果 129例患者肿瘤组织中NF-E1b阳性表达率68.22%,明显高于癌旁组织的6.98%(P<0.05)。随访患者3年,3年存活率为71.32%(92/129)。单因素分析提示,NF-E1b的表达与患者年龄、TNM分期、是否淋巴结转移以及是否远处转移有关(均P<0.05);3年存活率与肿瘤大小、TNM分期、肿瘤浸润深度、是否淋巴结转移、是否远处转移以及NF-E1b表达(均P<0.05)。多因素分析显示,TNM分期高、淋巴结转移以及远处转移是NF-E1b阳性表达的独立影响因素;肿瘤>4 cm、远处转移阳性以及NF-E1b表达阳性是患者3年存活率的独立危险因素。结论 NF-E1b在结直肠癌组织中的表达阳性率较高且与患者TNM分期、淋巴结转移以及远处转移有关,肿瘤>4 cm、远处转移阳性以及NF-E1b表达阳性是影响患者3年存活率的独立因素。

Objective To study the expression of NF-E1b in colorectal cancer patients and its relationship with clinical and pathological features and prognosis.Methods 129 patients underwent radical resection in our hospital from April 2010 to April 2013 was recruited as as the research subjects. Immunohistochemical method was used to detect the expression of NF-E1b in cancer tissues and adjacent tissues. We collected all the clinical data of patients and patients were followed up for 3 years.The relationship between the expression of NF-E1b protein was analyzed.The riskfactors of the 3 year survival rate of the patients were analyzed. Results The positive expression rate of NF-E1b in tumor tissues of 129 cases was 68.22%,which was significantly higher than that in adjacent tissues（P〈0. 05）.The patients were followed up for 3 years. 92 patients survived. 3-year survival rate was 71.32%.The expression of NF-E1b was closely related to the age,lymph node metastasis and distant metastasis,and had a significant effect on the 3-year survival rate of the patients（all P〈0. 05）.Multivariate analysis showed that high TNM stage,lymph node metastasis of colorectal cancer and distant metastasis of colorectal cancer were risk factors for NF-E1b positive expression. Tumor 4cm,positive distant metastasis and positive NF-E1b expression were the independent risk factors of the 3-year survival rate of patients.Conclusion The positive rate of NF-E1b expression in colorectal cancer was high,and was closely related to the age,lymph node metastasis and distant metastasis.The higher the positive expression rate of NF-E1b indicates worse prognosis.