康复新液治疗对高位肛周脓肿患者炎性因子、免疫功能及氧化应激水平的影响

Kangfuxin solution therapy on inflammatory factors,immune function and oxidative stress in patients with perianal abscess

目的探讨康复新液对高位肛周脓肿患者血清炎性因子、免疫功能及氧化应激等生化指标水平的影响。方法选择2014年9月至2016年10月本院收治的96例高位肛周脓肿患者为研究对象,随机分为对照组(n=48)和观察组(n=48)。所有患者均行一次性肛周脓肿根治手术,术后均给予5~7 d的抗生素治疗,术后第2 d均给予中药坐浴、生理盐水清洗、碘伏消毒。消毒后,对照组予凡士林纱条填塞引流,无菌纱布包扎及固定治疗;观察组予康复新液冲洗,采用康复新液纱条填塞引流,无菌纱布包扎固定治疗。比较治疗前后两组的血清炎性因子(TNF-α、IL-6及IL-8)、免疫细胞(CD3+、CD4+、CD8+和CD4+/CD8+)和氧化应激(SOD和MDA)水平。结果治疗前两组的上述指标水平比较,差异无统计学意义(P>0.05)。治疗后,两组的TNF-α、IL-6、IL-8和MDA水平较组内治疗前均显著降低,观察组显著低于对照组,差异均有统计学意义(均P<0.05);两组CD3+、CD4+、CD4+/CD8+和SOD水平较同组内治疗前均显著升高,观察组显著高于对照组,差异均有统计学意义(均P<0.05);两组CD8+水平组内及组间差异无统计学意义(P>0.05)。结论康复新液治疗可利于降低高位肛周脓肿患者术后的炎性因子水平,稳定机体的免疫细胞水平及改善氧化应激状态。

Objective To investigate the effect of Kangfuxin solution in the treatment of high perianal abscess and its effect on serum inflammatory factor,immune function and oxidative stress and other biochemical indicators level. Methods 96 patients with high perianal abscess were selected and randomly divided into control group（n = 48）and treatment group（n = 48）. All patients underwent radical resection of perianal abscess. Antibiotic treatment were given 5 ~7 d after surgery. Saline wash,and bath medicine,iodophor disinfection were given 2d postoperative. After disinfection,the control group were treated with vaseline gauze drainage,sterile gauze and fixation,and the treatment group was treated with Kangfuxin solution rinse with Kangfuxin gauze drainage,sterile gauze bandage fixation. The serum levels of inflammatory factors（TNF-α,IL-6 and IL-8）,immune function（CD3＋,CD4＋,CD8＋and CD4＋/CD8＋）and oxidative stress（SOD and MDA）levels were compared between the two groups before and after treatment. Results There was no significant difference between the two groups before treatment（P〉0. 05）. After treatment,the levels of TNF-α,IL-6,IL-8 and MDA in the two groups were significantly lower than those before treatment,and was significantly lower in the treatment group than those in the control group（P〈0. 05）. The levels of CD3＋,CD4＋,CD4＋/CD8＋and SOD were significantly higher than those before treatment,and was significantly higher in the treatment group than in the control group after treatment（P〈0. 05）. After treatment,the CD8＋levels in the two groups were lower than those before treatment,and was lower in the treatment group than in the control group,but the difference was not statistically significant（P〉0. 05）. Conclusion Kangfuxin solution treatment can significantly reduce the levels of inflammatory factors in patients with perianal abscess after operation,improve immune function and oxidative stress in the body. It has potential value for wide clinical application.