宫颈癌患者治疗后生活质量的影响因素分析

Influential factors of life quality of patients with cervical cancer after treatment

目的评估宫颈癌患者术后或放化疗后的生活质量(QOL)及其影响因素,以采用针对性治疗措施提高宫颈癌患者治疗后的生活质量。方法采用欧洲癌症研究与治疗组织生活质量核心调查表(EORTC QLQ-C30)对术后或放化疗后的100例宫颈癌患者进行生活质量调查。结果年龄对宫颈癌患者整体生活质量、角色功能、认知功能、疲乏和恶心、呕吐均有影响(t值分别为-0.3083、-2.114、-2.090、-2.495、2.619,均P<0.05)。家庭收入是影响整体生活质量、社会功能、经济困难的因素(t值分别为2.631、-3.082、-6.385,均P<0.05)。疾病分期是影响患者认知功能、情绪功能的因素(t值分别为-2.634、-4.861,均P<0.05)。肌层浸润深度、组织学转移、淋巴结转移均与宫颈癌患者的生活质量水平呈负相关。治疗方式是整体生活质量、疲乏、食欲减弱、经济困难的影响因素(t值分别为-5.171、3.471、2.023、2.738,均P<0.05)。结论重视宫颈癌的早诊早治,选择合理的治疗方式,为患者及其家人提供有针对性的治疗措施,可以提高宫颈癌患者治疗后的生活质量。

Objective To evaluate quality of life（ QOL） of cervical cancer patients treated with either surgery alone or surgery in combination with chemotherapy or/and radiotherapy and its influential factors and to design suitable treatment measures for improving patients＇ QOL after cervical cancer treatment. Methods QOL of 100 cervical cancer patients treated with surgery or radiochemotherapy was evaluated by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30（ EORTC QLQ-C30）. Results Age had an impact on overall QOL,role function,cognitive function,fatigue and nausea and vomiting of cervical cancer patients（ t value was-0. 3083,-2. 114,-2. 090,-2. 495 and 2. 619,respectively,all P 0. 05）. Household income was the factor affecting overall QOL,social function and economic difficulties（ t value was 2. 631,-3. 082 and-6. 385,respectively,all P 0. 05）. Stage of disease was influencing factor of cognitive function and emotional function of patients（ t value was-2. 634 and-4. 861,respectively,both P 0. 05）. Myometrial invasion depth,histological metastasis and lymphatic metastasis were negatively correlated with QOL of cervical cancer patients. Treatment method was influencing factor of overall QOL,fatigue,loss of appetite and economic difficulties（ t value was-5. 171,3. 471,2. 023 and 2. 738,respectively,all P 0. 05）. Conclusion Patients QOL after treatment of cervical cancer can be improved through paying attention to early diagnosis and treatment of cervical cancer,choosing reasonable treating method,and providing targeted treatment measures for patients and their families.