DWI评价乳腺浸润性导管癌生物学特征

DWI in evaluation on biological characteristics of breast invasive ductal carcinoma

目的探讨DWI评估乳腺浸润性导管癌(IDC)生物学特征的价值。方法回顾性分析经手术病理证实的87个乳腺浸润性导管癌的DWI数据,测量ADC值,评价并比较ADC值在不同腋窝淋巴结状态、组织学级别及分子学分型间的差异,并分析ADC值与腋窝淋巴结状态、组织学级别及分子学分型的相关性。结果淋巴结阳性病灶ADC值低于淋巴结阴性病灶(P=0.035),高级别乳腺癌ADC值低于中级别、低级别乳腺癌(P=0.021、0.002),ADC值在不同分子分型间差异无统计学意义。ADC值与组织学分级呈低度负相关(r_s=-0.357,P=0.001),与腋窝淋巴结转移及分子分型呈弱的负相关(r_s=-0.227,P=0.034;r_s=-0.093,P<0.001)。结论 DWI能够反映乳腺浸润性导管癌的生物学特征。

Objective To evaluate the value of DWI in assessing the biological characteristics of breast invasive ductal carcinoma（IDC）.Methods Eighty-seven IDC lesions confirmed by postoperative pathology were involved in this retrospective study.The ADC values of IDC were compared among different lymph node status,grades,and molecular subtype.The correlations of ADC value and lymph node status,grades,and molecular subtype were evaluated.Results The ADC value of IDC with positive lymph node was lower than that with negative lymph node（P=0.035）,and the ADC value of the high grade IDC was lower than those of medium grade IDC and low grade IDC（P=0.021,0.002）.There was no significant difference of ADC value between different molecular subtypes.There was low negative correlation of ADC value with grades（rs=-0.357,P=0.001）and week negative correlation of ADC value lymph node status and nolecular subtype（rs=-0.227,P=0.034;rs=-0.093,P0.001）.Conclusion DWI can provide useful information in evaluating the biological characteristics of IDC.