柴芩舒胃颗粒治疗胃食管反流病143例临床研究

Clinical Research of Chaiqin Shuwei Granule in the Treatment of 143 Cases with Gastroesophageal Reflux Disease

目的:观察柴芩舒胃颗粒治疗胃食管反流病患者的临床疗效及安全性。方法:采取随机对照的方法,将286例患者随机分为2组,各143例。治疗组予柴芩舒胃颗粒1袋每日3次治疗。对照组予奥美拉唑20mg,每日1次;吗叮啉10mg,每日3次治疗,2组治疗疗程均为8周,治疗前后观察记录临床症状,复查电子胃镜评价疗效。结果:治疗组胃镜下疗效有效率为82.52%,优于对照组(P<0.01);治疗组在改善烧心、胸痛、反酸、嗳气等临床症状及胃镜下黏膜积分方面优于对照组(P<0.01)。结论:柴芩舒胃颗粒治疗胃食管反流病疗效确切。

Objective： To observe the clinical efficacy and safety of Chaiqin Shuwei granule in the treatment of gastroesophageal reflux disease. Methods： Taking a randomized controlled approach, 286 patients were randomly divided into two groups, 143 cases in each group. Chaiqin Shuwei granule 1 bag and 3 times a day was used in the treatment group. Omeprazole 20mg/day, 1 time each day and Motilium 10mg/time, 3 times each day was applied in the control group. 2 groups of the treatment course were 8 weeks. Before and after treatment, the clinical symptoms was observed and the review the efficacy of electronic endoscopy evaluation. Results： The effective rate the treatment was 82.52% which was better than that in the control group（ P〈0.01）. The treatment group was superior to the control group in improving the clinical symptoms and endoscopic mucosal score of heartburn, chest pain, acid reflux and belching（ P〈0.01）. Conclusion： Chaiqin Shuwei granule is effective in the treatment of gastroesophageal reflux disease.