中医食疗系列方改善肿瘤患者化疗期间症状临床观察

Clinical Observation on Traditional Chinese Medicine Dietary Therapy for Improving Symptoms of Cancer Patients with Chemotherapy

目的:观察中医食疗系列方改善肿瘤患者化疗期间临床症状的疗效。方法:根据纳入与排除标准,入选病例20例,采用自身前后对照随机双盲方法。A组为第1周期采用食疗方,第2周期采用对照方;B组为第1周期采用对照方,第2周期采用食疗方。如此自身前后对照形成的检测样本最终因脱落3例,最后A组8例,B组9例,共纳入17例病人,两组病人各2个周期总共观察病例34人次。最后观察中医食疗方和对照方在化疗期间的生活质量及不适症状评分(乏力、食欲不振、大便干结、稀便、恶心呕吐、盗汗、自汗、口干咽燥、口苦、疼痛、烦躁易怒、失眠、其它,13个症状)的差异。结果:生活质量比较,化疗第10天食疗组与对照组有显著性差异(P<0.05);不适症状总评分比较,化疗第10天两组有显著性差异(P<0.05);其中,两组在乏力和食欲不振中均有显著性差异(P<0.05)。结论:中医食疗系列方对化疗期间患者的临床症状有一定改善作用,化疗第10天的不适症状低于对照组(P<0.05),第10天的生活质量评分高于对照组(P<0.05)。进一步探讨后,食疗组在改善乏力和食欲上与对照组有统计学差异,显示中医食疗系列方能对化疗患者带来助益。

This study was aimed to verify the effect of traditional Chinese medicine （TCM） dietary therapy in improving symptoms induced by chemotherapy. A total of 20 patients were included in the study according to the inclusion and exclusion criteria. The randomized autocontrol double-blind method was used in the trial. In group A, the dietary therapy was used in the first chemotherapy cycle, and the control therapy was used in the second chemotherapy cycle; and vice versa for group B. There were 3 cases fell out of the study. Finally, there were 8 cases in group A and 9 cases in group B. There were all together 17 patients. Observations were given on patients from both groups for 2 cycles. So the total observed case number was 34 person-time. Observations were given on differences of quality of life （QOL） and unpleasant symptoms （including fatigue, poor appetite, dry stool, loose stool, nausea and vomiting, night sweating, spontaneous sweating, dry mouth and throat, hitter taste in the mouth, pain, restlessness and irritable, insomnia and other symptoms） by TCM dietary therapy and control therapy on cancer patients during chemotherapy. The results showed that there was significant difference on the tenth day of chemotherapy from the QOL （P〈0.05）. There was significant difference on the tenth day of chemotherapy from the total score of unpleasant symptoms （P〈O.05）. Among them, there were significant differences on fatigue and poor appetite on the tenth day of chemotherapy （P〈0.05）. It was concluded that TCM dietary therapy has certain effects in the improvement of patients＇ clinical symptoms during chemotherapy. On the tenth day of chemotherapy, the unpleasant symptoms of TCM dietary therapy group were lower than that of the control group （P〈0.05）; the QOL score was higher in the treatment group than that of the control group （P〈0.05）. After in-depth discussion, there was statistical significance on dietary therapy in improving fatigue and poor appetite in the dietary therapy group. It demonstrated that TCM dietary therapy help patients during chemotherapy.