基于超短回波时间成像定量评估骨质疏松症患者骨皮质的研究

Ultra-short Echo-time Imaging in Quantitative Assessment of Cortical Bone in Cases with Osteoporosis

目的探讨磁共振成像超短回波时间成像技术(UTE)进行在体定量评估骨质疏松。方法以治疗前后完整随访的26例骨质疏松症患者及10例健康志愿者为研究对象,对所有受试者进行胫骨中下段骨皮质的超短回波时间MRI成像,通过其与参照物信号强度的比对得到被检测部位骨皮质短T2成分信号的相对比值,结合受试者骨密度及骨代谢物等观察该值在不同分组患者中的意义。结果正常对照组胫骨骨皮质的UTE总体相对信号(0.53±0.06)高于骨质疏松组(0.37±0.09),差异具有统计学意义(<0.05)。骨质疏松治疗后组的骨皮质相对信号强度高于治疗前,但两者无明显差异。治疗前后的骨吸收标志物CTX、P1NP与胫骨骨皮质相对信号强度存在负相关,治疗后的M-MID与其亦存在负相关。结论以参照物比对法定量胫骨骨皮质的UTE信号可潜在用于骨质疏松的评估。

Objective To discuss the application of ultra-short echo-time （UTE） imaging of MRI in quantitative as-sessment of osteoporosis in vivo. Methods 26 cases with osteoporosis and 10 norm were enrolled in the study and all the cases received UTE imaging of cortical bone in the lower tibia; the relative signal intensity ratio of the short T2 component of the cortical bone in the scanned site was gained through the comparison with the signal intensity of the reference, and the significance of the value in different groups was observed in combination with the bone mineral density and bone metabolites of the cases. Results The overall relative signal intensity o f UTE imaging in tibial cortical bone of the cases in normal control group （0.53±0.06） was higher than that in osteoporosis group （0.37±0.09） and the difference was of statistical significance （P〈0.05）; the relative signal intensity of cortical bone of the cases in osteoporosis group after treatment was higher than that before treatment but with no obvious difference; the relative signal intensity of CTX, P1NP and tibial cortical bone was in negative correlation after treatment to that before treatment, as well as M-MID after treatment. Conclusions The UTE imaging signal of cortical bone quantified by the comparison with the reference may be potentially applied in the assessment of osteoporosis.