莫西沙星治疗下呼吸道感染临床效果观察

Efficacy and safety of Moxifloxacin on lower respiratory tract infection

目的研究分析莫西沙星治疗下呼吸道感染的临床效果。方法采用随机分组方法,将我院收治的66例下呼吸道感染患者分为两组,各33例。在祛痰、镇咳、平喘等基础治疗的同时,观察组静脉注射莫西沙星400 mg,1次/d;对照组静脉注射左氧氟沙星400 mg,1次/d;疗程均为7~14 d。对比两组患者临床治疗效果。比较两组治愈患者的临床症状和体征消失时间。结果观察组治疗效果优于对照组(P<0.01);观察组治愈患者发热、咳痰和肺部啰音消失时间均短于对照组(P<0.05或P<0.01);两组患者不良反应发生率接近(P>0.05)。结论与左氧氟沙星相比,莫西沙星治疗下呼吸道感染的临床效果更好,值得推广。

Objective To study and analyze the clinical effect of moxifloxacin treatment of lower respiratory tract infection. Methods Sixty-six patients were divided into two groups,each group of 33 cases. Observation group of patients with intravenous injecion moxifloxacin 400 mg, 1/d, the control group iv levofloxacin 500 mg, 1/d to observe the stipulated time with 7 to 14 d, comparing two groups of patients with clinical therapeutic effect. Results The observation group of patients clinical total effective rate and improve the clinical symptoms were superior to control group patients, comparing the two groups with significant difference （ P 〈 0. 05 or P 〈 0. 01）. Conclusion Comparing with levofloxacin,moxifloxacin treatment of lower respiratory tract infection in clinical effect is better,it is worhy of promotion.