良性前列腺增生与雌激素关系的研究

Study on the relationship between benign prostatic hyperplastic and estrogen

目的 :探讨良性前列腺增生 (BPH)与雌激素受体 (ER)含量、血清雌二醇 (E2 )水平的关系。 方法 :利用免疫组织化学法和液闪法测定良性前列腺增生患者和健康人前列腺组织中的胞质和胞核ER含量及血清中E2 水平。 结果 :良性前列腺增生患者前列腺组织中胞质、胞核ER含量高于健康人 (P <0 .0 5 ) ,两组血清E2 水平差异不显著 (P >0 .0 5 )。 结论

Objectives:To explore the relationship between benign prostatic hyperplasia and estrogen receptor(ER)/estrogen(E 2). Methods:The content of ER/E 2 from 30 patients with BPH and 8 controls were evaluated by immunochemistry and radioimmunology. Results:The content of ER in BPH were significantly higher than controls(P<0.05),but E 2 of blood serum were not changed significantly between BPH and controls(P>0.05). Conclusions:Increased expression of ER in BPH was considered as an important factor in the pathogenesis of BPH.